Translating vitamin D transcriptomics to clinical evidence: Analysis of data in asthma and chronic obstructive pulmonary disease, followed by clinical data meta-analysis.
Asthma
Chronic obstructive pulmonary disease (COPD)
Meta-analysis
Transcriptome analysis
Vitamin D
Journal
The Journal of steroid biochemistry and molecular biology
ISSN: 1879-1220
Titre abrégé: J Steroid Biochem Mol Biol
Pays: England
ID NLM: 9015483
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
01
07
2019
revised:
29
09
2019
accepted:
22
10
2019
pubmed:
2
11
2019
medline:
7
7
2020
entrez:
1
11
2019
Statut:
ppublish
Résumé
Vitamin D (VitD) continues to trigger intense scientific controversy, regarding both its bi ological targets and its supplementation doses and regimens. In an effort to resolve this dispute, we mapped VitD transcriptome-wide events in humans, in order to unveil shared patterns or mechanisms with diverse pathologies/tissue profiles and reveal causal effects between VitD actions and specific human diseases, using a recently developed bioinformatics methodology. Using the similarities in analyzed transcriptome data (c-SKL method), we validated our methodology with osteoporosis as an example and further analyzed two other strong hits, specifically chronic obstructive pulmonary disease (COPD) and asthma. The latter revealed no impact of VitD on known molecular pathways. In accordance to this finding, review and meta-analysis of published data, based on an objective measure (Forced Expiratory Volume at one second, FEV
Identifiants
pubmed: 31669573
pii: S0960-0760(19)30398-X
doi: 10.1016/j.jsbmb.2019.105505
pii:
doi:
Substances chimiques
Vitamins
0
Vitamin D
1406-16-2
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105505Subventions
Organisme : European Research Council
ID : 617393
Pays : International
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.