Palladium(ii) complexes with thiosemicarbazones derived from pyrene as topoisomerase IB inhibitors.
Journal
Dalton transactions (Cambridge, England : 2003)
ISSN: 1477-9234
Titre abrégé: Dalton Trans
Pays: England
ID NLM: 101176026
Informations de publication
Date de publication:
12 Nov 2019
12 Nov 2019
Historique:
pubmed:
2
11
2019
medline:
19
3
2020
entrez:
1
11
2019
Statut:
ppublish
Résumé
New palladium complexes with thiosemicarbazonate ligands derived from pyrene exhibit potent antiproliferative activity against A2780 and cisplatin-resistant A2780Cis human ovarian cancer cells, which is dependent on substituent groups of the thiosemicarbazone ligands. Cellular accumulation and distribution studies confirmed that palladium enters the cell nucleus. DNA and topoisomerase IB studies show that one complex is a potent TopIB inhibitor, with selectivity for cancer versus normal cells.
Substances chimiques
Antineoplastic Agents
0
Coordination Complexes
0
Pyrenes
0
Thiosemicarbazones
0
Topoisomerase Inhibitors
0
Palladium
5TWQ1V240M
Cisplatin
Q20Q21Q62J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM