Possibilities and limitations of electrospun chitosan-coated polycaprolactone grafts for rotator cuff tear repair.
Aged
Animals
Biomechanical Phenomena
Chitosan
/ chemistry
Electrochemistry
/ methods
Humans
Male
Materials Testing
Orthopedic Procedures
/ methods
Polyesters
/ chemistry
Polymers
/ chemistry
Polyurethanes
/ chemistry
Porosity
Rats
Rats, Inbred Lew
Rotator Cuff
/ surgery
Rotator Cuff Injuries
/ pathology
Rupture
/ pathology
Stress, Mechanical
Sutures
Tendons
/ pathology
Tissue Engineering
/ methods
Tissue Scaffolds
/ chemistry
Wound Healing
biomechanics
chitosan
histology
polycaprolactone fiber implant
rat
rotator cuff
tendon
Journal
Journal of tissue engineering and regenerative medicine
ISSN: 1932-7005
Titre abrégé: J Tissue Eng Regen Med
Pays: England
ID NLM: 101308490
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
21
12
2018
revised:
27
09
2019
accepted:
17
10
2019
pubmed:
2
11
2019
medline:
9
7
2021
entrez:
1
11
2019
Statut:
ppublish
Résumé
Acute and chronic rotator cuff tears remain challenging for therapy. A wide range of therapeutic approaches were developed but re-tears and postoperative complications occur regularly. Especially in elderly people, the natural regeneration processes are decelerated, and graft materials are often necessary to stabilize the tendon-to-bone attachment and to improve the healing process. We here investigated in a small animal model a newly developed electrospun polycaprolactone fiber implant coated with a chitosan-polycaprolactone graft copolymer and compared these implants biomechanically and histologically with either a commercially available porous polyurethane implant (Biomerix 3D Scaffold) or suture-fixed tendons. Fifty-one rats were divided into three groups of 17 animals each. In the first surgery, the left infraspinatus tendons of all rats were detached, and the animals recovered for 4 weeks. In the second surgery, the tendons were fixed with suture material only (suture-fixed group; n = 17), whereas in the two experimental groups, the tendons were fixed with suture material and the polyurethane implant (Biomerix scaffold group; n = 17) or the modified electrospun polycaprolactone fiber implant (CS-g-PCL scaffold group; n=17), respectively. The unaffected right infraspinatus tendons were used as native controls. After a recovery of 8 weeks, all animals were clinically inconspicuous. In 12 animals of each group, repaired entheses were biomechanically tested for force at failure, stiffness, and modulus of elasticity, and in five animals, repaired entheses were analyzed histologically. Biomechanically, all parameters did not differ statistically significant between both implant groups, and the entheses failed typically at the surgical site. However, with respect to the force at failure, the median values of the two implant groups were smaller than the median value of the suture-fixed group. Histologically, the modified polycaprolactone fiber implant showed no acute inflammation processes, a good infiltration with cells, ingrowth of blood vessels and tendinous tissue, and a normal fibrous ensheathment. Further improvement of the implant material could be achieved by additional implementation of drug delivery systems. Therewith, the used CS-g-PCL fiber mat is a promising basic material to reach the goal of a clinically usable graft for rotator cuff tear repair.
Substances chimiques
Polyesters
0
Polymers
0
Polyurethanes
0
polycaprolactone
24980-41-4
Chitosan
9012-76-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
186-197Informations de copyright
© 2019 John Wiley & Sons, Ltd.
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