Serine-Arginine Protein Kinase SRPK2 Modulates the Assembly of the Active Zone Scaffolding Protein CAST1/ERC2.
CAST1/ERC2
SRPK
active zone
coiled-coil
self-aggregation
synapse
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
29 10 2019
29 10 2019
Historique:
received:
26
08
2019
revised:
08
10
2019
accepted:
11
10
2019
entrez:
2
11
2019
pubmed:
2
11
2019
medline:
18
8
2020
Statut:
epublish
Résumé
Neurons release neurotransmitters at a specialized region of the presynaptic membrane, the active zone (AZ), where a complex meshwork of proteins organizes the release apparatus. The formation of this proteinaceous cytomatrix at the AZ (CAZ) depends on precise homo- and hetero-oligomerizations of distinct CAZ proteins. The CAZ protein CAST1/ERC2 contains four coiled-coil (CC) domains that interact with other CAZ proteins, but also promote self-assembly, which is an essential step for its integration during AZ formation. The self-assembly and synaptic recruitment of the
Identifiants
pubmed: 31671734
pii: cells8111333
doi: 10.3390/cells8111333
pmc: PMC6912806
pii:
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
Cytoskeletal Proteins
0
ERC2 protein, human
0
Protein Serine-Threonine Kinases
EC 2.7.11.1
SRPK2 protein, human
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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