Natural Killer Cell-Derived Vesicular miRNAs: A New Anticancer Approach?
Clinical Trials as Topic
Cytokine Release Syndrome
/ etiology
Extracellular Vesicles
/ genetics
Humans
Immunotherapy
/ adverse effects
Killer Cells, Natural
/ cytology
MicroRNAs
/ metabolism
Neoplasms
/ genetics
Transplantation, Homologous
/ methods
Treatment Outcome
Tumor Escape
/ genetics
Tumor Microenvironment
/ genetics
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
01 01 2020
01 01 2020
Historique:
received:
08
05
2019
revised:
24
09
2019
accepted:
21
10
2019
pubmed:
2
11
2019
medline:
20
6
2020
entrez:
2
11
2019
Statut:
ppublish
Résumé
Natural killer (NK) cells are cytotoxic lymphocytes targeting virus-infected cells and cancer cells. Specific pro- and antikilling signals modulate the overall ability of NK cells to kill cancer cells, however, several immune-escape mechanisms can be enacted by cancer cells to avoid NK-mediated killing. Recently, increasing evidence has shown that extracellular vesicles (EV) released by NK cells carry proteins and miRNAs able to exert an antitumoral effect, even within a highly immune-suppressive tumor microenvironment. These recent findings suggest a possible use of NK-derived EVs as anticancer agents and propel the development of new strategies to enrich EVs with the most effective anticancer cargo as a promising new anticancer approach.
Identifiants
pubmed: 31672842
pii: 0008-5472.CAN-19-1450
doi: 10.1158/0008-5472.CAN-19-1450
pmc: PMC6942618
mid: NIHMS1541585
doi:
Substances chimiques
MicroRNAs
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
17-22Subventions
Organisme : NCI NIH HHS
ID : R01 CA215753
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA219024
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
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