Low-dose Oral Ketamine as a Procedural Analgesia in Pediatric Cancer Patients Undergoing Bone Marrow Aspirations at a Resource-limited Cancer Hospital in India.
Low-dose oral ketamine
pediatric cancer
procedural analgesia
Journal
Indian journal of palliative care
ISSN: 0973-1075
Titre abrégé: Indian J Palliat Care
Pays: United States
ID NLM: 101261221
Informations de publication
Date de publication:
Historique:
entrez:
2
11
2019
pubmed:
2
11
2019
medline:
2
11
2019
Statut:
ppublish
Résumé
Many pediatric cancer patients undergo repeated bone marrow aspirations (BMAs) for diagnostic and treatment evaluation purposes. Full anesthesia is the standard of care during this procedure in high-income countries. At hospitals with low resources in low/middle-income countries many children undergo these painful procedures without sufficient pain relief. This study aimed to evaluate the usefulness of low-dose oral ketamine as a procedural analgesic in a low-resource pediatric cancer care department. Pediatric patients, 4-15 years of age, who underwent BMAs between September 31 and November 30, 2018, were invited to participate. The study was designed as a placebo-controlled, single-blinded trial with three trial groups. Group K received 1.0 mg/kg of ketamine and Group KM received 1.0 mg/kg ketamine with an addition of 0.2 mg/kg midazolam, mixed in juice 30 min before procedures. Group A total of 87 patients were included in the study distributed with 29 in Group K, 29 in Group KM, and 29 in Group P. Seven patients were excluded, one patient denied participation and the remaining did not meet the inclusion criteria. There was no significant difference between the pain reported by the groups. A total of 69% patients in Group KM and 35% in Group K had somnolence reported as a side effect compared to 14% in Group P. We found no significant effects on the procedural pain in any of the treatment groups compared to placebo. There were only mild side effects. The doses of ketamine might be insufficient for this painful and stressful procedure.
Identifiants
pubmed: 31673202
doi: 10.4103/IJPC.IJPC_110_19
pii: IJPC-25-501
pmc: PMC6812415
doi:
Types de publication
Journal Article
Langues
eng
Pagination
501-507Informations de copyright
Copyright: © 2019 Indian Journal of Palliative Care.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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