Plasma neurofilament light associates with Alzheimer's disease metabolic decline in amyloid-positive individuals.
Alzheimer's disease
Biomarkers
Blood
Hypometabolism
Longitudinal
Neurodegeneration
Neurofilament light
PET
[18F]FDG
Journal
Alzheimer's & dementia (Amsterdam, Netherlands)
ISSN: 2352-8729
Titre abrégé: Alzheimers Dement (Amst)
Pays: United States
ID NLM: 101654604
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
entrez:
2
11
2019
pubmed:
2
11
2019
medline:
2
11
2019
Statut:
epublish
Résumé
Neurofilament light chain (NfL) is a promising blood biomarker to detect neurodegeneration in Alzheimer's disease (AD) and other brain disorders. However, there are limited reports of how longitudinal NfL relates to imaging biomarkers. We herein investigated the relationship between blood NfL and brain metabolism in AD. Voxelwise regression models tested the cross-sectional association between [ Higher concentrations of plasma and cerebrospinal fluid NfL were associated with reduced [ These findings indicate that plasma NfL is a proxy for neurodegeneration in AD-related regions in Aβ+ subjects.
Identifiants
pubmed: 31673598
doi: 10.1016/j.dadm.2019.08.002
pii: S2352-8729(19)30060-0
pmc: PMC6816316
doi:
Types de publication
Journal Article
Langues
eng
Pagination
679-689Subventions
Organisme : European Research Council
ID : 681712
Pays : International
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Informations de copyright
© 2019 The Authors.
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