Quinoline-Conjugated Ruthenacarboranes: Toward Hybrid Drugs with a Dual Mode of Action.
Antineoplastic Agents
/ chemical synthesis
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Coordination Complexes
/ chemical synthesis
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
MCF-7 Cells
Molecular Structure
Quinolines
/ chemistry
Ruthenium
/ chemistry
Structure-Activity Relationship
Tumor Cells, Cultured
autophagy
glioblastoma
quinoline
ruthenacarborane
self-assembly
Journal
ChemMedChem
ISSN: 1860-7187
Titre abrégé: ChemMedChem
Pays: Germany
ID NLM: 101259013
Informations de publication
Date de publication:
17 12 2019
17 12 2019
Historique:
received:
06
07
2019
revised:
19
10
2019
pubmed:
2
11
2019
medline:
10
9
2020
entrez:
2
11
2019
Statut:
ppublish
Résumé
The role of autophagy in cancer is often complex, ranging from tumor-promoting to -suppressing effects. In this study, two novel hybrid molecules were designed, containing a ruthenacarborane fragment conjugated with a known modulator of autophagy, namely a quinoline derivative. The complex closo-[3-(η
Identifiants
pubmed: 31675152
doi: 10.1002/cmdc.201900349
pmc: PMC6973020
doi:
Substances chimiques
Antineoplastic Agents
0
Coordination Complexes
0
Quinolines
0
Ruthenium
7UI0TKC3U5
quinoline
E66400VT9R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2061-2074Subventions
Organisme : Saxon State Ministry for Sciences and the Arts
ID : LAU-R-N-11-2-0615
Pays : International
Organisme : Serbian Ministry of Education
Pays : International
Organisme : Science and Technological Development
ID : 173013
Pays : International
Informations de copyright
©2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.
Références
Dalton Trans. 2015 Jan 28;44(4):1571-84
pubmed: 25464946
Biochem Pharmacol. 2018 Jan;147:170-182
pubmed: 29203368
Mini Rev Med Chem. 2009 Dec;9(14):1648-54
pubmed: 20088783
ChemMedChem. 2019 Dec 17;14(24):2061-2074
pubmed: 31675152
Sci Rep. 2018 Aug 3;8(1):11653
pubmed: 30076329
Genes Dev. 2007 Nov 15;21(22):2861-73
pubmed: 18006683
Prostate. 2018 Apr;78(5):390-400
pubmed: 29368435
Acta Crystallogr C Struct Chem. 2015 Jan;71(Pt 1):3-8
pubmed: 25567568
Chemistry. 2017 Jul 12;23(39):9233-9238
pubmed: 28605114
Autophagy. 2018;14(8):1435-1455
pubmed: 29940786
Cell Prolif. 2014 Oct;47(5):416-26
pubmed: 25139616
Bioorg Med Chem. 2012 Aug 1;20(15):4830-7
pubmed: 22748709
Nat Rev Cancer. 2007 Dec;7(12):961-7
pubmed: 17972889
Dalton Trans. 2012 Mar 7;41(9):2764-73
pubmed: 22249579
Saudi Pharm J. 2018 Jan;26(1):64-70
pubmed: 29379334
J Med Chem. 2016 Mar 10;59(5):2109-17
pubmed: 26849474
Inorg Chem. 2009 Feb 2;48(3):1122-31
pubmed: 19119867
Signal Transduct Target Ther. 2017 Sep 29;2:17040
pubmed: 29263927
Neurosurg Focus. 2015 Mar;38(3):E12
pubmed: 25727221
Cancer Lett. 2017 May 1;393:33-39
pubmed: 28216370
Dalton Trans. 2018 Feb 13;47(7):2192-2201
pubmed: 29359219
Dalton Trans. 2014 Jun 28;43(24):9045-51
pubmed: 24781711
Cell. 2010 Feb 5;140(3):313-26
pubmed: 20144757
Acta Crystallogr A Found Adv. 2015 Jan;71(Pt 1):3-8
pubmed: 25537383
Chem Rev. 2011 Nov 9;111(11):7035-62
pubmed: 21780840
J Biol Inorg Chem. 2009 Aug;14(6):863-71
pubmed: 19343380
Cancer Commun (Lond). 2018 Jun 19;38(1):35
pubmed: 29914561
Chem Soc Rev. 2019 Jul 1;48(13):3497-3512
pubmed: 31214680
Saudi Pharm J. 2013 Jan;21(1):1-12
pubmed: 23960814
Brain Pathol. 2012 Jan;22(1):89-98
pubmed: 22150924
Dalton Trans. 2017 Sep 28;46(36):12067-12080
pubmed: 28799598
Dalton Trans. 2007 Oct 10;(38):4240-51
pubmed: 17893811
Front Oncol. 2017 Jun 15;7:128
pubmed: 28674677
Autophagy. 2007 Nov-Dec;3(6):542-5
pubmed: 17611390
Pharmacol Res. 2016 Mar;105:62-73
pubmed: 26784390
Dalton Trans. 2016 Nov 14;45(42):16913-16921
pubmed: 27711842
Chem Rev. 2019 Jan 23;119(2):797-828
pubmed: 30295467
J Inorg Biochem. 2010 Sep;104(9):967-77
pubmed: 20605217
J Thorac Oncol. 2013 Jun;8(6):693-702
pubmed: 23575415
Eur J Med Chem. 2015 Jun 5;97:871-910
pubmed: 25073919
Microb Cell. 2016 Dec 01;3(12):588-596
pubmed: 28357331
Med Res Rev. 2018 May;38(3):775-828
pubmed: 28902434
J Nucl Med Radiat Ther. 2015;6(5):
pubmed: 26613064
J Med Chem. 2008 Jun 26;51(12):3466-79
pubmed: 18512900
ACS Chem Neurosci. 2014 May 21;5(5):335-9
pubmed: 24689484
Mini Rev Med Chem. 2016 Sep 2;16(15):1185-1194
pubmed: 27145851
Acta Oncol. 1994;33(6):685-91
pubmed: 7946449
Biochem J. 2018 Jun 11;475(11):1939-1954
pubmed: 29891531
Dalton Trans. 2016 Aug 16;45(33):13114-25
pubmed: 27264161