Enantiomeric 8,4'-type oxyneolignans from the root barks of Ailanthus altissima (Mill.) Swingle and their neuroprotective effects against H
Ailanthus
/ chemistry
Cell Line, Tumor
China
Humans
Hydrogen Peroxide
Lignans
/ isolation & purification
Molecular Structure
Neuroblastoma
Neuroprotective Agents
/ isolation & purification
Oxidative Stress
/ drug effects
Phytochemicals
/ isolation & purification
Plant Bark
/ chemistry
Plant Roots
/ chemistry
Stereoisomerism
8,4′-type oxyneolignans
Ailanthus altissima
Calculated ECD
Neuroprotective activity
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
04
10
2019
revised:
22
10
2019
accepted:
25
10
2019
pubmed:
5
11
2019
medline:
24
12
2019
entrez:
3
11
2019
Statut:
ppublish
Résumé
Ailanthus altissima Swingle is a deciduous tree, belonging to the Simaroubaceae family. Phytochemical investigation of the root barks of A. altissima showed the presence of eight pairs of enantiomeric 8,4'-type oxyneolignans (1a/1b-8a/8b) including nine undescribed compounds (1b, 2a, 3a/3b, 4a/4b, 5b, 7b, 8a). Their structures were elucidated by comprehensive spectroscopic analyses, and their absolute configurations were determined by comparison of the experimental and quantum chemical calculations of electronic circular dichroism (ECD) curves. In addition, their neuroprotective effects against H
Identifiants
pubmed: 31676396
pii: S0367-326X(19)31994-X
doi: 10.1016/j.fitote.2019.104403
pii:
doi:
Substances chimiques
Lignans
0
Neuroprotective Agents
0
Phytochemicals
0
Hydrogen Peroxide
BBX060AN9V
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104403Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.