MiR-146a down-regulates inflammatory response by targeting TLR3 and TRAF6 in Coxsackievirus B infection.
Animals
Coxsackievirus Infections
/ immunology
Cytokines
/ metabolism
Down-Regulation
Enterovirus B, Human
/ genetics
Fibroblasts
/ immunology
HeLa Cells
Humans
Inflammation
/ immunology
Intracellular Signaling Peptides and Proteins
/ genetics
Mice
Mice, Inbred BALB C
MicroRNAs
/ genetics
NF-kappa B
/ genetics
Signal Transduction
Toll-Like Receptor 3
/ genetics
Coxsackievirus B
NF-κB
TLR3
TRAF6
miR-146a
Journal
RNA (New York, N.Y.)
ISSN: 1469-9001
Titre abrégé: RNA
Pays: United States
ID NLM: 9509184
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
20
05
2019
accepted:
28
10
2019
pubmed:
5
11
2019
medline:
29
4
2020
entrez:
3
11
2019
Statut:
ppublish
Résumé
Coxsackievirus B (CVB) is the major cause of human myocarditis and dilated cardiomyopathy. Toll-like receptor 3 (TLR3) is an intracellular sensor to detect pathogen's dsRNA. TLR3, along with TRAF6, triggers an inflammatory response through NF-κB signaling pathway. In the cells infected with CVB type 3 (CVB3), the abundance of miR-146a was significantly increased. The role of miR-146a in CVB infection is unclear. In this study, TLR3 and TRAF6 were identified as the targets of miR-146a. The elevated miR-146a inhibited NF-κB translocation and subsequently down-regulated proinflammatory cytokine expression in the CVB3-infected cells. Therefore, the NF-κB pathway can be doubly blocked by miR-146a through targeting of TLR3 and TRAF6. MiR-146a may be a negative regulator on inflammatory response and an intrinsic protective factor in CVB infection.
Identifiants
pubmed: 31676570
pii: rna.071985.119
doi: 10.1261/rna.071985.119
pmc: PMC6913124
doi:
Substances chimiques
Cytokines
0
Intracellular Signaling Peptides and Proteins
0
MIRN146 microRNA, human
0
MicroRNAs
0
NF-kappa B
0
TLR3 protein, human
0
Tifab protein, human
0
Toll-Like Receptor 3
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
91-100Informations de copyright
© 2020 Fei et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.
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