Human stem cell models: lessons for pancreatic development and disease.
embryonic
pancreatic development
stem cell
Journal
Genes & development
ISSN: 1549-5477
Titre abrégé: Genes Dev
Pays: United States
ID NLM: 8711660
Informations de publication
Date de publication:
01 11 2019
01 11 2019
Historique:
entrez:
3
11
2019
pubmed:
5
11
2019
medline:
18
12
2019
Statut:
ppublish
Résumé
A comprehensive understanding of mechanisms that underlie the development and function of human cells requires human cell models. For the pancreatic lineage, protocols have been developed to differentiate human pluripotent stem cells (hPSCs) into pancreatic endocrine and exocrine cells through intermediates resembling in vivo development. In recent years, this differentiation system has been employed to decipher mechanisms of pancreatic development, congenital defects of the pancreas, as well as genetic forms of diabetes and exocrine diseases. In this review, we summarize recent insights gained from studies of pancreatic hPSC models. We discuss how genome-scale analyses of the differentiation system have helped elucidate roles of chromatin state, transcription factors, and noncoding RNAs in pancreatic development and how the analysis of cells with disease-relevant mutations has provided insight into the molecular underpinnings of genetically determined diseases of the pancreas.
Identifiants
pubmed: 31676735
pii: 33/21-22/1475
doi: 10.1101/gad.331397.119
pmc: PMC6824472
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1475-1490Informations de copyright
© 2019 Gaertner et al.; Published by Cold Spring Harbor Laboratory Press.
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