Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease.

Aged Animals Case-Control Studies Female Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Humans Male Mice Mice, Inbred C57BL Middle Aged Plasminogen Activator Inhibitor 1 / genetics Risk Factors United Kingdom / epidemiology Vascular Diseases / epidemiology Venous Thromboembolism / epidemiology

Journal

Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904

Informations de publication

Date de publication:
11 2019
Historique:
received: 05 03 2019
accepted: 24 09 2019
pubmed: 5 11 2019
medline: 23 1 2020
entrez: 3 11 2019
Statut: ppublish

Résumé

Venous thromboembolism is a significant cause of mortality

Identifiants

DOI: 10.1038/s41588-019-0519-3 PMID: 31676865 PMC: PMC6858581
pubmed: 31676865
doi: 10.1038/s41588-019-0519-3
pii: 10.1038/s41588-019-0519-3
pmc: PMC6858581
mid: NIHMS1540585
doi:

Substances chimiques

Plasminogen Activator Inhibitor 1 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

1574-1579

Subventions

Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL142711
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL140203
Pays : United States
Organisme : CSRD VA
ID : IK2 CX001780
Pays : United States
Organisme : NIH HHS
ID : S10 OD020069
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL148050
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134894
Pays : United States

Commentaires et corrections

Type : CommentIn

Références

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Auteurs

Derek Klarin (D)

Veterans Affairs Boston Healthcare System, Boston, MA, USA.
Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Division of Vascular Surgery and Endovascular Therapy, University of Florida School of Medicine, Gainesville, FL, USA.
ORCID: 0000-0002-4636-5780

Emma Busenkell (E)

Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Renae Judy (R)

Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.
Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Julie Lynch (J)

Veterans Affairs Informatics and Computing Infrastructure, Veterans Affairs Salt Lake City Health Care System, Salt Lake City, UT, USA.
University of Massachusetts College of Nursing & Health Sciences, Boston, MA, USA.
ORCID: 0000-0003-0108-2127

Michael Levin (M)

Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.
Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0002-9937-9932

Jeffery Haessler (J)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Krishna Aragam (K)

Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Mark Chaffin (M)

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0002-1234-5562

Mary Haas (M)

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Sara Lindström (S)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.

Themistocles L Assimes (TL)

Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
ORCID: 0000-0003-2349-0009

Jie Huang (J)

Massachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston, MA, USA.

Kyung Min Lee (K)

Veterans Affairs Informatics and Computing Infrastructure, Veterans Affairs Salt Lake City Health Care System, Salt Lake City, UT, USA.
Center for Healthcare Organization and Implementation Research, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA, USA.
Boston University School of Public Health, Department of Health Law, Policy & Management, Boston, MA, USA.
ORCID: 0000-0001-8995-0448

Qing Shao (Q)

Center for Healthcare Organization and Implementation Research, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA, USA.

Jennifer E Huffman (JE)

Massachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston, MA, USA.
ORCID: 0000-0002-9672-2491

Christopher Kabrhel (C)

Center for Vascular Emergencies, Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA.
Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Yunfeng Huang (Y)

Department of Epidemiology, Emory University Rollins School of Public Health, Department of Biomedical Informatics Emory University School of Medicine, Atlanta, GA, USA.
Atlanta Veterans Affairs Health Care System, Decatur, GA, USA.

Yan V Sun (YV)

Department of Epidemiology, Emory University Rollins School of Public Health, Department of Biomedical Informatics Emory University School of Medicine, Atlanta, GA, USA.
Atlanta Veterans Affairs Health Care System, Decatur, GA, USA.

Marijana Vujkovic (M)

Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.
Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, Philadelphia, PA, USA.
ORCID: 0000-0003-4924-5714

Danish Saleheen (D)

Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.
Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, Philadelphia, PA, USA.

Donald R Miller (DR)

Center for Healthcare Organization and Implementation Research, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA, USA.
Boston University School of Public Health, Department of Health Law, Policy & Management, Boston, MA, USA.

Peter Reaven (P)

Phoenix Veterans Affairs Health Care System, Phoenix, AZ, USA.

Scott DuVall (S)

Veterans Affairs Informatics and Computing Infrastructure, Veterans Affairs Salt Lake City Health Care System, Salt Lake City, UT, USA.
Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.

William E Boden (WE)

Massachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston, MA, USA.

Saiju Pyarajan (S)

Massachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston, MA, USA.
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Alex P Reiner (AP)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

David-Alexandre Trégouët (DA)

Bordeaux Population Health Research Center (INSERM UMR S 1219), University of Bordeaux, Bordeaux, France.

Peter Henke (P)

Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA.

Charles Kooperberg (C)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

J Michael Gaziano (JM)

Massachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston, MA, USA.
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

John Concato (J)

Clinical Epidemiology Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA.
Department of Medicine, Yale University School of Medicine, New Haven, CT, USA.

Daniel J Rader (DJ)

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Kelly Cho (K)

Massachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston, MA, USA.
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Kyong-Mi Chang (KM)

Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.
Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Peter W F Wilson (PWF)

Atlanta Veterans Affairs Health Care System, Decatur, GA, USA.
Emory Clinical Cardiovascular Research Institute, Atlanta, GA, USA.

Nicholas L Smith (NL)

Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle, WA, USA.
Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.

Christopher J O'Donnell (CJ)

Veterans Affairs Boston Healthcare System, Boston, MA, USA.
Massachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston, MA, USA.
Cardiovascular Medicine Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Philip S Tsao (PS)

Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.
Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
ORCID: 0000-0001-7274-9318

Sekar Kathiresan (S)

Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Verve Therapeutics, Cambridge, MA, USA.
ORCID: 0000-0002-6724-032X

Andrea Obi (A)

Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI, USA.

Scott M Damrauer (SM)

Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.
Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0001-8009-1632

Pradeep Natarajan (P)

Veterans Affairs Boston Healthcare System, Boston, MA, USA. pnatarajan@mgh.harvard.edu.
Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. pnatarajan@mgh.harvard.edu.
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. pnatarajan@mgh.harvard.edu.
Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. pnatarajan@mgh.harvard.edu.
ORCID: 0000-0001-8402-7435

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Genome-wide association analysis of venous...
questionsmedicales.fr › Eucaryotes › Animaux › Genome-wide association analysis of venous...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Genome-wide association analysis of venous...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Genome-wide association analysis of venous...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Genome-wide association analysis of venous...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Genome-wide association analysis of venous...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genome-wide association analysis of venous...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Genome-wide association analysis of venous...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Genome-wide association analysis of venous...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Genome-wide association analysis of venous...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Inhibiteurs d'activateurs du plasminogène › Inhibiteur-1 d'activateur du plasminogène › Genome-wide association analysis of venous...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Genome-wide association analysis of venous...
questionsmedicales.fr › Régions géographiques › Europe › Royaume-Uni › Genome-wide association analysis of venous...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Genome-wide association analysis of venous...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Embolie et thrombose › Thromboembolie › Thromboembolisme veineux › Genome-wide association analysis of venous...