Dynamic single-slice CT estimates whole-lung dual-energy CT variables in pigs with and without experimental lung injury.
Acute lung injury
Artificial
Contrast media
Respiration
Swine
Tomography
X-ray computed
Journal
Intensive care medicine experimental
ISSN: 2197-425X
Titre abrégé: Intensive Care Med Exp
Pays: Germany
ID NLM: 101645149
Informations de publication
Date de publication:
01 Nov 2019
01 Nov 2019
Historique:
received:
23
07
2019
accepted:
01
10
2019
entrez:
3
11
2019
pubmed:
5
11
2019
medline:
5
11
2019
Statut:
epublish
Résumé
Dynamic single-slice CT (dCT) is increasingly used to examine the intra-tidal, physiological variation in aeration and lung density in experimental lung injury. The ability of dCT to predict whole-lung values is unclear, especially for dual-energy CT (DECT) variables. Additionally, the effect of inspiration-related lung movement on CT variables has not yet been quantified. Eight domestic pigs were studied under general anaesthesia, including four following saline-lavage surfactant depletion (lung injury model). DECT, dCT and whole-lung images were collected at 12 ventilatory settings. Whole-lung single energy scans images were collected during expiratory and inspiratory apnoeas at positive end-expiratory pressures from 0 to 20 cmH Mean CT density and volume fractions of soft tissue, gas, iodinated blood, atelectasis, poor aeration, normal aeration and overdistension correlated between dCT and the whole lung (r Overall, dCT closely approximates whole-lung aeration and density. This approximation is improved by inspiration where a decrease in CT density and atelectasis can be interpreted as physiological rather than artefactual.
Sections du résumé
BACKGROUND
BACKGROUND
Dynamic single-slice CT (dCT) is increasingly used to examine the intra-tidal, physiological variation in aeration and lung density in experimental lung injury. The ability of dCT to predict whole-lung values is unclear, especially for dual-energy CT (DECT) variables. Additionally, the effect of inspiration-related lung movement on CT variables has not yet been quantified.
METHODS
METHODS
Eight domestic pigs were studied under general anaesthesia, including four following saline-lavage surfactant depletion (lung injury model). DECT, dCT and whole-lung images were collected at 12 ventilatory settings. Whole-lung single energy scans images were collected during expiratory and inspiratory apnoeas at positive end-expiratory pressures from 0 to 20 cmH
RESULTS
RESULTS
Mean CT density and volume fractions of soft tissue, gas, iodinated blood, atelectasis, poor aeration, normal aeration and overdistension correlated between dCT and the whole lung (r
CONCLUSIONS
CONCLUSIONS
Overall, dCT closely approximates whole-lung aeration and density. This approximation is improved by inspiration where a decrease in CT density and atelectasis can be interpreted as physiological rather than artefactual.
Identifiants
pubmed: 31676929
doi: 10.1186/s40635-019-0273-y
pii: 10.1186/s40635-019-0273-y
pmc: PMC6825104
doi:
Types de publication
Journal Article
Langues
eng
Pagination
59Subventions
Organisme : Vetenskapsrådet (SE)
ID : K2015-99X-2273101-4
Organisme : Physiological Society (GB)
ID : Formenti 2018
Organisme : Hjärt-Lungfonden (SE)
ID : 20170531
Organisme : Department of Health
ID : II-AR-0410-12031
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17164
Pays : United Kingdom
Organisme : Department of Health
ID : II-LA-0214-20006
Pays : United Kingdom
Organisme : Vetenskapsrådet
ID : K2015-99X-2273101-4
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