Assessment of age-related decline of neurovascular coupling responses by functional near-infrared spectroscopy (fNIRS) in humans.
Aging
Cognitive aging
Functional near-infrared spectroscopy
Neurovascular coupling
VCI
VCID
Vascular cognitive impairment and dementia
fNIRS
Journal
GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
07
10
2019
accepted:
11
10
2019
pubmed:
5
11
2019
medline:
22
5
2020
entrez:
3
11
2019
Statut:
ppublish
Résumé
Preclinical studies provide strong evidence that age-related impairment of neurovascular coupling (NVC) plays a causal role in the pathogenesis of vascular cognitive impairment (VCI). NVC is a critical homeostatic mechanism in the brain, responsible for adjustment of local cerebral blood flow to the energetic needs of the active neuronal tissue. Recent progress in geroscience has led to the identification of critical cellular and molecular mechanisms involved in neurovascular aging, identifying these pathways as targets for intervention. In order to translate the preclinical findings to humans, there is a need to assess NVC in geriatric patients as an endpoint in clinical studies. Functional near-infrared spectroscopy (fNIRS) is a non-invasive neuroimaging technique that enables the investigation of local changes in cerebral blood flow, quantifying task-related changes in oxygenated and deoxygenated hemoglobin concentrations. In the present overview, the basic principles of fNIRS are introduced and the application of this technique to assess NVC in older adults with implications for the design of studies on the mechanistic underpinnings of VCI is discussed.
Identifiants
pubmed: 31676966
doi: 10.1007/s11357-019-00122-x
pii: 10.1007/s11357-019-00122-x
pmc: PMC6885078
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
495-509Subventions
Organisme : NIGMS NIH HHS
ID : 1P20GM125528
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103447
Pays : United States
Organisme : NINDS NIH HHS
ID : R01-NS056218
Pays : United States
Organisme : NINDS NIH HHS
ID : R01-NS085002
Pays : United States
Organisme : NIA NIH HHS
ID : P30AG050911
Pays : United States
Organisme : NIA NIH HHS
ID : R01-AG038747
Pays : United States
Organisme : NIA NIH HHS
ID : R01-AG055395
Pays : United States
Organisme : NIGMS NIH HHS
ID : GM104938
Pays : United States
Organisme : NIA NIH HHS
ID : R01-AG047879
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM125528
Pays : United States
Organisme : NINDS NIH HHS
ID : R01-NS100782
Pays : United States
Organisme : NIA NIH HHS
ID : T32AG052363
Pays : United States
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