Magnesium supplementation for the treatment of restless legs syndrome and periodic limb movement disorder: A systematic review.

Dietary Supplements Humans Magnesium / administration & dosage Nocturnal Myoclonus Syndrome / drug therapy Polysomnography Restless Legs Syndrome / drug therapy
Diet Ekbom-willis disease MagMin Magnesium Mg Periodic limb movement disorder Restless legs syndrome Supplement Wittmaack-ekbom syndrome

Journal

Sleep medicine reviews
ISSN: 1532-2955
Titre abrégé: Sleep Med Rev
Pays: England
ID NLM: 9804678

Informations de publication

Date de publication:
12 2019
Historique:
received: 04 03 2019
revised: 02 10 2019
accepted: 07 10 2019
pubmed: 5 11 2019
medline: 23 5 2020
entrez: 4 11 2019
Statut: ppublish

Résumé

Magnesium supplementation is often suggested for restless legs syndrome (RLS) or period limb movement disorder (PLMD) based on anecdotal evidence that it relieves symptoms and because it is also commonly recommended for leg cramps. We aimed to review all articles reporting the effects of magnesium supplementation on changes in RLS and/or PLMD. We conducted a systematic search looking for all relevant articles and then two reviewers read all article titles and abstracts to identify relevant studies. Eligible studies were scored for their quality as interventional trials. We found 855 abstracts and 16 of these could not be definitively excluded for not addressing all aspects of our research question. Seven full-text articles were unlocatable and one was ineligible which left eight studies with relevant data. One was a randomised placebo-controlled trial, three were case series and four were case studies. The RCT did not find a significant treatment effect of magnesium but may have been underpowered. After quality appraisal and synthesis of the evidence we were unable to make a conclusion as to the effectiveness of magnesium for RLS/PLMD. It is not clear whether magnesium helps relieve RLS or PLMD or in which patient groups any benefit might be seen.

Identifiants

DOI: 10.1016/j.smrv.2019.101218 PMID: 31678660
pubmed: 31678660
pii: S1087-0792(19)30186-8
doi: 10.1016/j.smrv.2019.101218
pii:
doi:

Substances chimiques

Magnesium I38ZP9992A

Types de publication

Journal Article Research Support, Non-U.S. Gov't Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

101218

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Nathaniel S Marshall (NS)

Centre for Integrated Research and Understanding of Sleep (CIRUS), Woolcock Institute of Medical Research, The University of Sydney, Australia; Faculty of Medicine and Health, Sydney Nursing School, The University of Sydney, Sydney, Australia. Electronic address: nathaniel.marshall@sydney.edu.au.

Yasmina Serinel (Y)

Centre for Integrated Research and Understanding of Sleep (CIRUS), Woolcock Institute of Medical Research, The University of Sydney, Australia; Department of Respiratory and Sleep Medicine, Nepean Hospital, Kingswood, NSW, Australia.

Roo Killick (R)

Centre for Integrated Research and Understanding of Sleep (CIRUS), Woolcock Institute of Medical Research, The University of Sydney, Australia.

Julia M Child (JM)

University Library, The University of Sydney, Sydney, Australia.

Isabelle Raisin (I)

University Library, The University of Sydney, Sydney, Australia.

Callum M Berry (CM)

Centre for Integrated Research and Understanding of Sleep (CIRUS), Woolcock Institute of Medical Research, The University of Sydney, Australia; Faculty of Medicine and Health, Sydney Nursing School, The University of Sydney, Sydney, Australia.

Tea Lallukka (T)

Centre for Integrated Research and Understanding of Sleep (CIRUS), Woolcock Institute of Medical Research, The University of Sydney, Australia; Faculty of Medicine, Department of Public Health, University of Helsinki, Finland.

Rick Wassing (R)

Centre for Integrated Research and Understanding of Sleep (CIRUS), Woolcock Institute of Medical Research, The University of Sydney, Australia.

Richard Ww Lee (RW)

Centre for Integrated Research and Understanding of Sleep (CIRUS), Woolcock Institute of Medical Research, The University of Sydney, Australia.

Rajeev Ratnavadivel (R)

Central Coast Local Health Network, NSW, Australia; Faculty of Health and Medicine, University of Newcastle, Australia.

Hima Vedam (H)

Department of Respiratory and Sleep Medicine, Liverpool Hospital, Australia; South Western Sydney Clinical School, University of New South Wales, Australia; Ingham Institute of Applied Medical Research, Sydney, New South Wales, Australia.

Ron Grunstein (R)

Centre for Integrated Research and Understanding of Sleep (CIRUS), Woolcock Institute of Medical Research, The University of Sydney, Australia; Faculty of Medicine and Health, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia; Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital Camperdown NSW Australia.

Keith Kh Wong (KK)

Centre for Integrated Research and Understanding of Sleep (CIRUS), Woolcock Institute of Medical Research, The University of Sydney, Australia; Faculty of Medicine and Health, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia; Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital Camperdown NSW Australia.

Camilla M Hoyos (CM)

Centre for Integrated Research and Understanding of Sleep (CIRUS), Woolcock Institute of Medical Research, The University of Sydney, Australia; Faculty of Science, School of Psychology, The University of Sydney, Sydney, NSW, Australia.

Elizabeth A Cayanan (EA)

Centre for Integrated Research and Understanding of Sleep (CIRUS), Woolcock Institute of Medical Research, The University of Sydney, Australia; Faculty of Medicine and Health, Sydney Nursing School, The University of Sydney, Sydney, Australia.

Maria Comas (M)

Centre for Integrated Research and Understanding of Sleep (CIRUS), Woolcock Institute of Medical Research, The University of Sydney, Australia; Faculty of Medicine and Health, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.

Julia L Chapman (JL)

Centre for Integrated Research and Understanding of Sleep (CIRUS), Woolcock Institute of Medical Research, The University of Sydney, Australia.

Brendon J Yee (BJ)

Centre for Integrated Research and Understanding of Sleep (CIRUS), Woolcock Institute of Medical Research, The University of Sydney, Australia; Faculty of Medicine and Health, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia; Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital Camperdown NSW Australia.

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Classifications MeSH

questionsmedicales.fr › Aliments et boissons › Aliments › Compléments alimentaires › Magnesium supplementation for the treatment of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Magnesium supplementation for the treatment of...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux légers › Magnésium › Magnesium supplementation for the treatment of...
questionsmedicales.fr › Maladies du système nerveux › Syndrome des mouvements périodiques nocturnes des membres › Magnesium supplementation for the treatment of...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Monitorage physiologique › Polysomnographie › Magnesium supplementation for the treatment of...
questionsmedicales.fr › Troubles mentaux › Troubles de la veille et du sommeil › Parasomnies › Syndrome des jambes sans repos › Magnesium supplementation for the treatment of...