Change in Blood Pressure Variability Among Treated Elderly Hypertensive Patients and Its Association With Mortality.
ambulatory blood pressure
cardiovascular events
change in blood pressure variability
elderly
hypertension
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
05 11 2019
05 11 2019
Historique:
entrez:
5
11
2019
pubmed:
5
11
2019
medline:
15
12
2020
Statut:
ppublish
Résumé
Background Information is scarce regarding effects of antihypertensive medication on blood pressure variability (BPV) and associated clinical outcomes. We examined whether antihypertensive treatment changes BPV over time and whether such change (decline or increase) has any association with long-term mortality in an elderly hypertensive population. Methods and Results We used data from a subset of participants in the Second Australian National Blood Pressure study (n=496) aged ≥65 years who had 24-hour ambulatory blood pressure recordings at study entry (baseline) and then after a median of 2 years while on treatment (follow-up). Weighted day-night systolic BPV was calculated for both baseline and follow-up as a weighted mean of daytime and nighttime blood pressure standard deviations. The annual rate of change in BPV over time was calculated from these BPV estimates. Furthermore, we classified both BPV estimates as
Identifiants
pubmed: 31679444
doi: 10.1161/JAHA.119.012630
pmc: PMC6898807
doi:
Substances chimiques
Antihypertensive Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e012630Investigateurs
A Bruce
(A)
P Beckinsale
(P)
J Thompson
(J)
M McMurchie
(M)
G Fraser
(G)
D Gleave
(D)
V Cope
(V)
F DeLooze
(F)
S Moore
(S)
C Dibben
(C)
J Newbury
(J)
B McDermott
(B)
K Willson
(K)
C Bear
(C)
S Harrap
(S)
C Johnston
(C)
P Ryan
(P)
M Brown
(M)
P Ryan
(P)
P Fletcher
(P)
M Feneley
(M)
E Dewar
(E)
J Marley
(J)
J Marley
(J)
J Moss
(J)
P Webb
(P)
P Glasziou
(P)
F Boyle
(F)
J Primrose
(J)
L Piterman
(L)
F De Looze
(F)
J Dickinson
(J)
J Gambrill
(J)
P Joseph
(P)
G Donnan
(G)
T Morgan
(T)
J Whitworth
(J)
S MacMahon
(S)
C Silagy
(C)
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