Influence of osmolarity and hydration on the tear resistance of the human amniotic membrane.
Biomedical engineering
Fracture mechanics
Human amniotic membrane
PPROM
Structural mechanics
Journal
Journal of biomechanics
ISSN: 1873-2380
Titre abrégé: J Biomech
Pays: United States
ID NLM: 0157375
Informations de publication
Date de publication:
02 01 2020
02 01 2020
Historique:
received:
05
06
2019
revised:
15
08
2019
accepted:
13
10
2019
pubmed:
5
11
2019
medline:
6
10
2020
entrez:
5
11
2019
Statut:
ppublish
Résumé
The amnion is considered to be the load-bearing part of the fetal membranes. We investigated the influence of osmolarity of the testing medium and hydration on its fracture toughness. Mode I fracture tests revealed that physiological variations in the bath osmolarity do not influence the tear resistance of amnion, while larger changes, i.e. from physiological saline solution to distilled water, lead to a significant reduction of the fracture toughness. Uniaxial tensile tests on collagen hydrogels confirmed the reduction in toughness, suggesting that lower bath osmolarity triggers changes in the failure properties of single collagen fibers. Prenatal surgeries, in particular fetoscopic procedures with partial amniotic carbon dioxide insufflation, might result in dehydration of the amnion. Dehydration induced a brittle behavior; however, subsequent rehydration for 15 min resulted in a similar tear resistance as for the fresh tissue.
Identifiants
pubmed: 31679754
pii: S0021-9290(19)30666-9
doi: 10.1016/j.jbiomech.2019.109419
pii:
doi:
Substances chimiques
Water
059QF0KO0R
Carbon Dioxide
142M471B3J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109419Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.