Are targeted prostate biopsies ready to replace systematic prostate biopsies?
Las biopsias de próstata dirigidas ¿están listas para reemplazar las biopsias de próstata sistemáticas?
Aged
Biopsy
/ methods
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Humans
Image-Guided Biopsy
/ methods
Kallikreins
/ blood
Magnetic Resonance Imaging, Interventional
/ methods
Male
Middle Aged
Neoplasm Grading
Prospective Studies
Prostate
/ diagnostic imaging
Prostate-Specific Antigen
/ blood
Prostatic Neoplasms
/ blood
Biopsias de próstata dirigidas
Biopsias dirigidas a fusión cognitiva
Cognitive fusion targeted biopsies
Cáncer de próstata
Multi-parametric MRI
Prostate cancer
Resonancia magnética multiparamétrica
Targeted prostate biopsies
Journal
Actas urologicas espanolas
ISSN: 2173-5786
Titre abrégé: Actas Urol Esp (Engl Ed)
Pays: Spain
ID NLM: 101771154
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
29
12
2017
revised:
07
06
2018
accepted:
09
06
2018
pubmed:
5
11
2019
medline:
3
10
2020
entrez:
5
11
2019
Statut:
ppublish
Résumé
To evaluate the efficacy and efficiency of systematic prostatic biopsy (SPB) and cognitive fusion PB (CFPB) to diagnose prostate cancer (PCa) and significant PCa (SPCa), and to analyse if CFPB could safely replace SPB. A cohort of 314 consecutive men having PI-RADS ≥2 in a pre-biopsy 3T mp-MRI were prospectively subjected to trans-rectal ultrasound CFPB (two cores per suspicious area until a maximum of three areas) and a 12 peripheral core SPB. SPCa was considered when the WHO grade was higher than 2 (Gleason 4+3 or higher). PCa was diagnosed in 133 patients (42.4%), being 83 (62.4%) SPCa. SPB detected PCa in 114 men (85.7%) while CFPB in 103 (77.4%), P<.001. SPB detected SPCa in 64 men (77.1%) while CFPB in 71 (85.5%), P<.001. In 52 of the 81 men (64.2%) SPCa was detected in SPB and CFPB. In 19 men SPCa was only detected in CFPB (23.5%) while in 10, it was only detected in SPB (12.3%). 33.1 cores were needed to diagnose one PCa in SPB while 8.5 in CFPB, P<.001. 58.9 cores were needed to diagnose one SPCa in SPB, while 12.4 in CFPB, P<.001. CFPB are more effective and also more efficient than SPBs in detecting SPCa. However, CFPBs still can't safely replace SPBs because they are not able to detect up to 15% of SPCa.
Identifiants
pubmed: 31679807
pii: S0210-4806(19)30116-0
doi: 10.1016/j.acuro.2018.06.011
pii:
doi:
Substances chimiques
KLK3 protein, human
EC 3.4.21.-
Kallikreins
EC 3.4.21.-
Prostate-Specific Antigen
EC 3.4.21.77
Types de publication
Comparative Study
Journal Article
Langues
eng
spa
Sous-ensembles de citation
IM
Pagination
573-578Informations de copyright
Copyright © 2019 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.