Combined effects of maternal exposure to fungicides on behavioral development in F
Animals
Behavior, Animal
/ drug effects
Body Weight
/ drug effects
Exploratory Behavior
/ drug effects
Female
Fungicides, Industrial
/ adverse effects
Imidazoles
/ adverse effects
Lactation
/ drug effects
Litter Size
/ drug effects
Male
Maternal Exposure
/ adverse effects
Mice
Pregnancy
Prenatal Exposure Delayed Effects
Reproduction
/ drug effects
Thiabendazole
/ adverse effects
behavioral development
enilconazole
fungicide
imazalil
maternal exposure
mice
movement activity
reproductive toxicity
spontaneous behavior
thiabendazole
Journal
Birth defects research
ISSN: 2472-1727
Titre abrégé: Birth Defects Res
Pays: United States
ID NLM: 101701004
Informations de publication
Date de publication:
15 01 2020
15 01 2020
Historique:
received:
04
06
2019
revised:
08
10
2019
accepted:
17
10
2019
pubmed:
5
11
2019
medline:
25
5
2021
entrez:
5
11
2019
Statut:
ppublish
Résumé
Few published studies are reported for neurobehavioral toxicity of combined exposure to fungicides in mammals. This study was aimed to evaluate reproductive and neurobehavioral effects of maternal exposure to combined fungicides in mice. Imazalil (IMZ) and thiabendazole (TBZ) were given in the diet to provide levels of 0/0% (control), 0.0015/0.006% (IMZ/TBZ), 0.006/0.018%, and 0.024/0.054% during the gestation and lactation periods. Selected reproductive and neurobehavioral parameters were measured in the F No adverse effect of IMZ/TBZ was observed in litter size, litter weight, or sex ratio at birth. The average body weight of male and female offspring was increased significantly in treatment groups during the lactation period. With respect to behavioral developmental parameters, the swimming head angle on PND 7 of male offspring was significantly accelerated in the treatment groups. After weaning, the movement time of exploratory behavior shortened in a significant dose-related manner in adult males of the F The high-dose level of IMZ/TBZ in the present study produced several adverse effects in neurobehavioral parameters after weaning without concurrent chemical administration in mice.
Sections du résumé
BACKGROUND
Few published studies are reported for neurobehavioral toxicity of combined exposure to fungicides in mammals. This study was aimed to evaluate reproductive and neurobehavioral effects of maternal exposure to combined fungicides in mice.
METHODS
Imazalil (IMZ) and thiabendazole (TBZ) were given in the diet to provide levels of 0/0% (control), 0.0015/0.006% (IMZ/TBZ), 0.006/0.018%, and 0.024/0.054% during the gestation and lactation periods. Selected reproductive and neurobehavioral parameters were measured in the F
RESULTS
No adverse effect of IMZ/TBZ was observed in litter size, litter weight, or sex ratio at birth. The average body weight of male and female offspring was increased significantly in treatment groups during the lactation period. With respect to behavioral developmental parameters, the swimming head angle on PND 7 of male offspring was significantly accelerated in the treatment groups. After weaning, the movement time of exploratory behavior shortened in a significant dose-related manner in adult males of the F
CONCLUSIONS
The high-dose level of IMZ/TBZ in the present study produced several adverse effects in neurobehavioral parameters after weaning without concurrent chemical administration in mice.
Substances chimiques
Fungicides, Industrial
0
Imidazoles
0
enilconazole
6K0NOF3XQ6
Thiabendazole
N1Q45E87DT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
141-161Informations de copyright
© 2019 Wiley Periodicals, Inc.
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