Short-Term Fever-Range Hyperthermia Accelerates NETosis and Reduces Pro-inflammatory Cytokine Secretion by Human Neutrophils.
NETosis
NETs
cytokines
hyperthermia
neutrophils
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
03
06
2019
accepted:
23
09
2019
entrez:
5
11
2019
pubmed:
5
11
2019
medline:
30
10
2020
Statut:
epublish
Résumé
Fever is a hallmark of infections and inflammatory diseases, represented by an increase of 1-4°C in core body temperature. Fever-range hyperthermia (FRH) has been shown to increase neutrophil recruitment to local sites of infection. Here, we evaluated the impact of a short period (1 h) of FRH (STFRH) on pro-inflammatory and bactericidal human neutrophil functions. STFRH did not affect neutrophil spontaneous apoptosis but reverted the lipopolysaccharide (LPS)-induced anti-apoptotic effect compared with that under normothermic conditions. Furthermore, STFRH accelerated phorbol myristate acetate (PMA)-induced NETosis evaluated either by the nuclear DNA decondensation at 2 h post-stimulation or by the increase in extracellular DNA that colocalized with myeloperoxidase (MPO) at 4 h post-stimulation. Increased NETosis upon STFRH was associated with an increase in reactive oxygen species (ROS) production but not in autophagy levels. STFRH also increased NETosis in response to
Identifiants
pubmed: 31681277
doi: 10.3389/fimmu.2019.02374
pmc: PMC6813732
doi:
Substances chimiques
CXCL8 protein, human
0
IL1B protein, human
0
Interleukin-1beta
0
Interleukin-8
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2374Informations de copyright
Copyright © 2019 Keitelman, Sabbione, Shiromizu, Giai, Fuentes, Rosso, Ledo, Miglio Rodriguez, Guzman, Geffner, Galletti, Jancic, Gómez and Trevani.
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