Randomized controlled trial of cefazolin monotherapy versus cefazolin plus azithromycin single dose prophylaxis for cesarean deliveries: A developing country's perspective.
Antimicrobial prophylaxis
azithromycin
cefazolin
cesarean delivery
Journal
Journal of family medicine and primary care
ISSN: 2249-4863
Titre abrégé: J Family Med Prim Care
Pays: India
ID NLM: 101610082
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
27
07
2019
revised:
21
08
2019
accepted:
03
09
2019
entrez:
5
11
2019
pubmed:
5
11
2019
medline:
5
11
2019
Statut:
epublish
Résumé
To compare the efficacy of pre-incision intravenous single doses of cefazolin versus cefazolin plus azithromycin as an antibiotic prophylaxis in cesarean delivery (CD). This was a single-center, double blind, randomized controlled trial conducted in the PGIMER, Chandigarh. 200 women undergoing elective/emergency cesarean section were randomized. Group A received single dose of cefazolin plus placebo while Group B received single dose of cefazolin plus azithromycin. Primary outcome evaluated was occurrence of surgical site infections (SSI); secondary outcomes included incidence of febrile morbidity, UTI, endometritis, neonatal outcome, total cost of antibiotics, and duration of hospital stay in both the study arms. Descriptive statistics and χ There was an overall significant reduction in the incidence of SSI (15% vs 3%; Tertiary care hospitals in developing countries such as India can opt for the cefazolin plus azithromycin as antimicrobial prophylaxis during CD to maximize the efficacy as well as for decreasing the cost burden of postoperative infections.
Identifiants
pubmed: 31681684
doi: 10.4103/jfmpc.jfmpc_593_19
pii: JFMPC-8-3015
pmc: PMC6820430
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3015-3021Informations de copyright
Copyright: © 2019 Journal of Family Medicine and Primary Care.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
Obstet Gynecol. 2001 Nov;98(5 Pt 1):745-50
pubmed: 11704163
Obstet Gynecol. 1998 Aug;92(2):262-8
pubmed: 9699764
Indian J Pharmacol. 2019 Mar-Apr;51(2):126-127
pubmed: 31142950
Matern Health Neonatol Perinatol. 2017 Jul 5;3:12
pubmed: 28690864
J Med Assoc Thai. 1992 Mar;75(3):173-7
pubmed: 1506796
J Pharm Technol. 2019 Aug;35(4):146-154
pubmed: 34861003
J Reprod Med. 1986 Jan;31(1):27-30
pubmed: 3950878
P T. 2015 Apr;40(4):277-83
pubmed: 25859123
Br J Anaesth. 2011 Nov;107(5):757-61
pubmed: 21857016
Obstet Med. 2014 Sep;7(3):98-102
pubmed: 27512432
Cost Eff Resour Alloc. 2018 Dec 18;16:66
pubmed: 30574024
Am J Infect Control. 1999 Apr;27(2):97-132; quiz 133-4; discussion 96
pubmed: 10196487
Obstet Gynecol. 2003 Jun;101(6):1183-9
pubmed: 12798523
Obstet Gynecol. 2008 Jan;111(1):51-6
pubmed: 18165392
South Med J. 2003 Oct;96(10):992-5
pubmed: 14570343
J Pharm Technol. 2019 Aug;35(4):155-163
pubmed: 34861032
EMBO Rep. 2015 May;16(5):566-70
pubmed: 25851646
Infect Control Hosp Epidemiol. 1999 Aug;20(8):543-8
pubmed: 10466554