Towards Raman spectroscopy of urine as screening tool.

Animals Asthma Discriminant Analysis Mass Screening Mice Principal Component Analysis Spectrum Analysis, Raman
Raman spectroscopy linear discriminant analysis principal component analysis screening urine

Journal

Journal of biophotonics
ISSN: 1864-0648
Titre abrégé: J Biophotonics
Pays: Germany
ID NLM: 101318567

Informations de publication

Date de publication:
01 2020
Historique:
received: 16 04 2019
revised: 05 07 2019
accepted: 29 07 2019
pubmed: 5 11 2019
medline: 24 6 2021
entrez: 5 11 2019
Statut: ppublish

Résumé

For the screening purposes urine is an especially attractive biofluid, since it offers easy and noninvasive sample collection and provides a snapshot of the whole metabolic status of the organism, which may change under different pathological conditions. Raman spectroscopy (RS) has the potential to monitor these changes and utilize them for disease diagnostics. The current study utilizes mouse models aiming to compare the feasibility of the urine based RS combined with chemometrics for diagnosing kidney diseases directly influencing urine composition and respiratory tract diseases having no direct connection to urine formation. The diagnostic models for included diseases were built using principal component analysis with linear discriminant analysis and validated with a leave-one-mouse-out cross-validation approach. Considering kidney disorders, the accuracy of 100% was obtained in discrimination between sick and healthy mice, as well as between two different kidney diseases. For asthma and invasive pulmonary aspergillosis achieved accuracies were noticeably lower, being, respectively, 77.27% and 78.57%. In conclusion, our results suggest that RS of urine samples not only provides a solution for a rapid, sensitive and noninvasive diagnosis of kidney disorders, but also holds some promises for the screening of nonurinary tract diseases.

Identifiants

DOI: 10.1002/jbio.201900143 PMID: 31682320
pubmed: 31682320
doi: 10.1002/jbio.201900143
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e201900143

Informations de copyright

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Auteurs

Olga Žukovskaja (O)

Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University, Jena, Germany.
Research Campus Infectognostic, Philosophenweg, Jena, Germany.
Leibniz Institute of Photonic Technology, Member of the Research Alliance "Leibniz Health Technologies", Jena, Germany.

Oleg Ryabchykov (O)

Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University, Jena, Germany.
Leibniz Institute of Photonic Technology, Member of the Research Alliance "Leibniz Health Technologies", Jena, Germany.

Maria Straßburger (M)

Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute, Jena, Germany.

Thorsten Heinekamp (T)

Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute, Jena, Germany.

Axel A Brakhage (AA)

Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University, Jena, Germany.
Institute of Microbiology, Friedrich Schiller University, Jena, Germany.

Christopher J Hennings (CJ)

Institut für Humangenetik, Universitätsklinikum, Jena, Germany.

Christian A Hübner (CA)

Institut für Humangenetik, Universitätsklinikum, Jena, Germany.

Michael Wegmann (M)

Division of Asthma Exacerbation & Regulation, Program Area Asthma & Allergy, Leibniz-Center for Medicine and Biosciences, Member of the Research Alliance "Leibniz Health Technologies", Jena, Germany.
Airway Research Center North (ARCN), Member of the German Center for Lung Research, Borstel, Germany.

Dana Cialla-May (D)

Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University, Jena, Germany.
Research Campus Infectognostic, Philosophenweg, Jena, Germany.
Leibniz Institute of Photonic Technology, Member of the Research Alliance "Leibniz Health Technologies", Jena, Germany.

Thomas W Bocklitz (TW)

Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University, Jena, Germany.
Leibniz Institute of Photonic Technology, Member of the Research Alliance "Leibniz Health Technologies", Jena, Germany.

Karina Weber (K)

Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University, Jena, Germany.
Research Campus Infectognostic, Philosophenweg, Jena, Germany.
Leibniz Institute of Photonic Technology, Member of the Research Alliance "Leibniz Health Technologies", Jena, Germany.
ORCID: 0000-0003-4907-8645

Jürgen Popp (J)

Institute of Physical Chemistry and Abbe Center of Photonics, Friedrich Schiller University, Jena, Germany.
Research Campus Infectognostic, Philosophenweg, Jena, Germany.
Leibniz Institute of Photonic Technology, Member of the Research Alliance "Leibniz Health Technologies", Jena, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Towards Raman spectroscopy of urine as screening tool.
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Hypersensibilité respiratoire › Asthme › Towards Raman spectroscopy of urine as screening tool.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse discriminante › Towards Raman spectroscopy of urine as screening tool.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pratiques en santé publique › Dépistage de masse › Towards Raman spectroscopy of urine as screening tool.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Towards Raman spectroscopy of urine as screening tool.
questionsmedicales.fr › Techniques d'investigation › Analyse en composantes principales › Towards Raman spectroscopy of urine as screening tool.
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Analyse spectrale Raman › Towards Raman spectroscopy of urine as screening tool.