Quinolizidine alkaloids from Sophora tonkinensis and their anti-inflammatory activities.

Alkaloids / isolation & purification Animals Animals, Genetically Modified Anti-Inflammatory Agents / isolation & purification Azocines China Mice Molecular Structure Phytochemicals / isolation & purification Plant Roots / chemistry Quinolizidines / isolation & purification Quinolizines RAW 264.7 Cells Sophora / chemistry Zebrafish
Alkaloid Anti-inflammatory activity Sophora tonkinensis Gagnep.

Journal

Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R

Informations de publication

Date de publication:
Nov 2019
Historique:
received: 14 09 2019
revised: 15 10 2019
accepted: 20 10 2019
pubmed: 5 11 2019
medline: 24 12 2019
entrez: 5 11 2019
Statut: ppublish

Résumé

Two new quinolizidine-based alkaloids (2 and 12), along with ten known ones (1, 3-11) were isolated from the roots of S. tonkinensis. Their structures were determined by spectroscopic data (including NMR, MS, IR, and UV), X-ray single crystal diffraction, electronic circular dichroism analyses (ECD), and comparing with related literatures. Compounds 1, 3-12 at non-toxic concentrations exhibited potent anti-inflammatory activities according to in vitro and in vivo anti-inflammatory tests. Among them, (-)-anagyrine (4), sophocarpine (8), 14β-hydroxymatrine (10), and 7β-sophoramine (12) showed more potent in vitro anti-inflammatory activities, and 5α,14β-dihydroxymatrine (2), (-)-anagyrine (4), sophocarpine (8), and 5α-hydroxymatrine (9) exhibited better in vivo anti-inflammatory effects.

Identifiants

DOI: 10.1016/j.fitote.2019.104391 PMID: 31682871
pubmed: 31682871
pii: S0367-326X(19)31844-1
doi: 10.1016/j.fitote.2019.104391
pii:
doi:

Substances chimiques

Alkaloids 0
Anti-Inflammatory Agents 0
Azocines 0
Phytochemicals 0
Quinolizidines 0
Quinolizines 0
sophocarpine 6483-15-4
sophoramine 6882-66-2
anagyrine FYU1U980Q9

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

104391

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Li-Jun He (LJ)

Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), School of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China.

Jun-Shan Liu (JS)

School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.

Ding Luo (D)

Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), School of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China.

Yuan-Ru Zheng (YR)

School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.

Yu-Bo Zhang (YB)

Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), School of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China.

Guo-Cai Wang (GC)

Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), School of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China. Electronic address: twangguocai@jnu.edu.cn.

Yao-Lan Li (YL)

Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), School of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China. Electronic address: tliyl@jnu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Alcaloïdes › Quinolizidine alkaloids from Sophora...
questionsmedicales.fr › Eucaryotes › Animaux › Quinolizidine alkaloids from Sophora...
questionsmedicales.fr › Stades d'organismes › Organismes génétiquement modifiés › Animal génétiquement modifié › Quinolizidine alkaloids from Sophora...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Quinolizidine alkaloids from Sophora...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azocines › Quinolizidine alkaloids from Sophora...
questionsmedicales.fr › Régions géographiques › Asie › Extrême-Orient › Chine › Quinolizidine alkaloids from Sophora...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Quinolizidine alkaloids from Sophora...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Quinolizidine alkaloids from Sophora...
questionsmedicales.fr › Facteurs biologiques › Composés phytochimiques › Quinolizidine alkaloids from Sophora...
questionsmedicales.fr › Structures de plante › Racines de plante › Quinolizidine alkaloids from Sophora...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinolizines › Quinolizidines › Quinolizidine alkaloids from Sophora...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinolizines › Quinolizidine alkaloids from Sophora...
questionsmedicales.fr › Cellules › Cellules RAW 264.7 › Quinolizidine alkaloids from Sophora...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Fabaceae › Sophora › Quinolizidine alkaloids from Sophora...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Quinolizidine alkaloids from Sophora...