Interfering with airway nerves in cough associated with asthma.
Airway nerve
Asthma
Bronchial thermoplasty
Chronic cough
Cough reflex sensitivity
Tiotropium
Journal
Pulmonary pharmacology & therapeutics
ISSN: 1522-9629
Titre abrégé: Pulm Pharmacol Ther
Pays: England
ID NLM: 9715279
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
10
07
2019
revised:
13
10
2019
accepted:
13
10
2019
pubmed:
5
11
2019
medline:
4
9
2020
entrez:
5
11
2019
Statut:
ppublish
Résumé
Cough is a troublesome and often refractory symptom of asthma, which is associated with poor control of disease. The pathogenesis of asthmatic cough has mainly been attributed to bronchoconstriction, but recent evidence indicate that cough reflex hypersensitivity or neuronal dysfunction is a feature of asthma, even in those with mild stable disease. This is likely resistant to the mainstay treatment ICS/LABA which inhibits classic asthmatic response. Such refractory cough might manifest more predominantly in the day-time rather than night-time. Treatment options of such refractory cough or cough reflex hypersensitivity in asthma targeting the nerves (LTRAs, tiotropium, and potentially bronchial thermoplasty) are discussed.
Identifiants
pubmed: 31683030
pii: S1094-5539(19)30172-5
doi: 10.1016/j.pupt.2019.101854
pii:
doi:
Substances chimiques
Anti-Asthmatic Agents
0
Antitussive Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101854Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.