Replicating predictive serum correlates of greater translocator protein distribution volume in brain.


Journal

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
ISSN: 1740-634X
Titre abrégé: Neuropsychopharmacology
Pays: England
ID NLM: 8904907

Informations de publication

Date de publication:
05 2020
Historique:
received: 25 07 2019
accepted: 11 10 2019
revised: 24 09 2019
pubmed: 5 11 2019
medline: 24 6 2021
entrez: 5 11 2019
Statut: ppublish

Résumé

Greater activation of glia, a key component of neuroinflammation, is an important process to target in neuropsychiatric illnesses. However, the magnitude of gliosis varies across cases so low-cost predictors are needed to stratify subjects for clinical trials. Here, several such blood serum measures were assessed in relation to TSPO V

Identifiants

pubmed: 31683271
doi: 10.1038/s41386-019-0561-y
pii: 10.1038/s41386-019-0561-y
pmc: PMC7162884
doi:

Substances chimiques

Receptors, GABA 0
TSPO protein, human 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

925-931

Subventions

Organisme : CIHR
ID : GSD-157948
Pays : Canada
Organisme : CIHR
ID : MOP-136955
Pays : Canada

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Auteurs

Sophia Attwells (S)

Research Imaging Centre and Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.
Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.

Elaine Setiawan (E)

Research Imaging Centre and Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.

Alan A Wilson (AA)

Research Imaging Centre and Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.
Department of Psychiatry, University of Toronto, 250 College Street, Toronto, ON, M5T 1R8, Canada.

Pablo M Rusjan (PM)

Research Imaging Centre and Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.

Laura Miler (L)

Research Imaging Centre and Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.

Cynthia Xu (C)

Research Imaging Centre and Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.

Celeste Hutton (C)

Research Imaging Centre and Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.

Muhammad I Husain (MI)

Department of Psychiatry, University of Toronto, 250 College Street, Toronto, ON, M5T 1R8, Canada.

Stephen Kish (S)

Research Imaging Centre and Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.
Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.
Department of Psychiatry, University of Toronto, 250 College Street, Toronto, ON, M5T 1R8, Canada.

Neil Vasdev (N)

Research Imaging Centre and Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.

Sylvain Houle (S)

Research Imaging Centre and Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada.
Department of Psychiatry, University of Toronto, 250 College Street, Toronto, ON, M5T 1R8, Canada.

Jeffrey H Meyer (JH)

Research Imaging Centre and Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada. jeff.meyer@camhpet.ca.
Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. jeff.meyer@camhpet.ca.
Department of Psychiatry, University of Toronto, 250 College Street, Toronto, ON, M5T 1R8, Canada. jeff.meyer@camhpet.ca.

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Classifications MeSH