EPO and TMBIM3/GRINA Promote the Activation of the Adaptive Arm and Counteract the Terminal Arm of the Unfolded Protein Response after Murine Transient Cerebral Ischemia.
Adenine
/ analogs & derivatives
Animals
Apoptosis
/ drug effects
Cells, Cultured
Endoplasmic Reticulum Stress
/ drug effects
Erythropoietin
/ pharmacology
Glucose
/ metabolism
Indoles
/ pharmacology
Infarction, Middle Cerebral Artery
/ genetics
Ischemic Attack, Transient
/ genetics
Male
Membrane Proteins
/ genetics
Mice, 129 Strain
Mice, Inbred C57BL
Mice, Knockout
Nerve Tissue Proteins
/ genetics
Neuroprotective Agents
/ pharmacology
Oxygen
/ metabolism
Sulfonamides
/ pharmacology
Thapsigargin
/ pharmacology
Thiophenes
/ pharmacology
Tunicamycin
/ pharmacology
Unfolded Protein Response
/ drug effects
EPO
GRINA
GSK-2606414
IRE1α
PERK
STF-083010
UPR
neuroprotection
stroke
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 Oct 2019
31 Oct 2019
Historique:
received:
25
09
2019
revised:
24
10
2019
accepted:
30
10
2019
entrez:
6
11
2019
pubmed:
7
11
2019
medline:
31
3
2020
Statut:
epublish
Résumé
Ischemic stroke is known to cause the accumulation of misfolded proteins and loss of calcium homeostasis leading to impairment of endoplasmic reticulum (ER) function. The unfolded protein response (UPR) is an ER-located and cytoprotective pathway that aims to resolve ER stress. Transmembrane BAX inhibitor-1 motif-containing (TMBIM) protein family member TMBIM3/GRINA is highly expressed in the brain and mostly located at the ER membrane suppressing ER calcium release by inositol-1,4,5-trisphosphate receptors. GRINA confers neuroprotection and is regulated by erythropoietin (EPO) after murine cerebral ischemia. However, the role of GRINA and the impact of EPO treatment on the post-ischemic UPR have not been elucidated yet. We subjected GRINA-deficient (
Identifiants
pubmed: 31683519
pii: ijms20215421
doi: 10.3390/ijms20215421
pmc: PMC6862264
pii:
doi:
Substances chimiques
7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine
0
Grina protein, mouse
0
Indoles
0
Membrane Proteins
0
Nerve Tissue Proteins
0
Neuroprotective Agents
0
STF 083010
0
Sulfonamides
0
Thiophenes
0
Tunicamycin
11089-65-9
Erythropoietin
11096-26-7
Thapsigargin
67526-95-8
Glucose
IY9XDZ35W2
Adenine
JAC85A2161
Oxygen
S88TT14065
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medizinische Fakultät, RWTH Aachen University
ID : START 111/17 PH
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