Synergy Between Low Dose Metronomic Chemotherapy and the pH-centered Approach Against Cancer.
Administration, Metronomic
Angiogenesis Inhibitors
/ administration & dosage
Antineoplastic Combined Chemotherapy Protocols
/ therapeutic use
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
/ metabolism
Drug Synergism
Humans
Hydrogen-Ion Concentration
Neoplasms
/ blood supply
Neovascularization, Pathologic
/ metabolism
Vascular Endothelial Growth Factor A
/ metabolism
angiogenesis
cancer metabolism
cancer proton transporters
cancer reversed pH gradient
metastasis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 Oct 2019
31 Oct 2019
Historique:
received:
11
09
2019
revised:
25
10
2019
accepted:
29
10
2019
entrez:
6
11
2019
pubmed:
7
11
2019
medline:
31
3
2020
Statut:
epublish
Résumé
Low dose metronomic chemotherapy (MC) is becoming a mainstream treatment for cancer in veterinary medicine. Its mechanism of action is anti-angiogenesis by lowering vascular endothelial growth factor (VEGF) and increasing trombospondin-1 (TSP1). It has also been adopted as a compassionate treatment in very advanced human cancer. However, one of the main limitations of this therapy is its short-term effectiveness: 6 to 12 months, after which resistance develops. pH-centered cancer treatment (pHT) has been proposed as a complementary therapy in cancer, but it has not been adopted or tested as a mainstream protocol, in spite of existing evidence of its advantages and benefits. Many of the factors directly or indirectly involved in MC and anti-angiogenic treatment resistance are appropriately antagonized by pHT. This led to the testing of an association between these two treatments. Preliminary evidence indicates that the association of MC and pHT has the ability to reduce anti-angiogenic treatment limitations and develop synergistic anti-cancer effects. This review will describe each of these treatments and will analyze the fundamentals of their synergy.
Identifiants
pubmed: 31683667
pii: ijms20215438
doi: 10.3390/ijms20215438
pmc: PMC6862380
pii:
doi:
Substances chimiques
Angiogenesis Inhibitors
0
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
0
SPZ1 protein, human
0
Vascular Endothelial Growth Factor A
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest
Références
Oncogene. 2012 Jan 12;31(2):200-12
pubmed: 21685934
Cancer Res. 2007 Nov 15;67(22):10627-30
pubmed: 18006801
Cancer Metastasis Rev. 2007 Jun;26(2):225-39
pubmed: 17440684
Nat Rev Cancer. 2011 Aug 11;11(9):671-7
pubmed: 21833026
Cancer Res. 2000 Mar 15;60(6):1541-5
pubmed: 10749120
Mol Cancer Ther. 2011 Dec;10(12):2298-308
pubmed: 21926191
Science. 2000 Aug 18;289(5482):1197-202
pubmed: 10947988
Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17069-74
pubmed: 17942672
Cancer Cell. 2009 Mar 3;15(3):232-9
pubmed: 19249681
J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S135-9
pubmed: 11078359
Growth Factors. 1992;7(4):261-6
pubmed: 1284870
Blood. 2000 Jul 1;96(1):34-40
pubmed: 10891427
Mol Cell. 2000 Feb;5(2):311-20
pubmed: 10882072
Trends Endocrinol Metab. 2003 Jan;14(1):44-50
pubmed: 12475611
Am J Physiol. 1984 Apr;246(4 Pt 2):R409-38
pubmed: 6326601
Nat Rev Cancer. 2005 Oct;5(10):786-95
pubmed: 16175178
Srp Arh Celok Lek. 1996 May-Jun;124(5-6):120-3
pubmed: 9102830
J Exp Clin Cancer Res. 2010 May 08;29:44
pubmed: 20459683
J Biol Chem. 2012 Oct 12;287(42):35161-9
pubmed: 22932900
Cancer Lett. 2015 Jan 28;356(2 Pt B):697-703
pubmed: 25449440
Nature. 2005 Apr 7;434(7034):786-92
pubmed: 15815633
Nat Rev Drug Discov. 2007 May;6(5):357-72
pubmed: 17464295
Am J Physiol Cell Physiol. 2002 Aug;283(2):C396-403
pubmed: 12107048
Lab Invest. 2004 Aug;84(8):989-98
pubmed: 15170218
Mol Neurobiol. 2018 May;55(5):4127-4135
pubmed: 28597396
J Cell Physiol. 1982 Jul;112(1):1-4
pubmed: 6980886
Handb Exp Pharmacol. 2018;249:31-61
pubmed: 28405776
Eur J Pharmacol. 2011 Aug 1;663(1-3):9-16
pubmed: 21596032
Genes Cancer. 2010 Jan;1(1):12-25
pubmed: 21779425
Cancer Lett. 2001 Sep 28;171(1):11-6
pubmed: 11485823
Biochim Biophys Acta. 2011 Apr;1812(4):558-64
pubmed: 21081159
Biochem Biophys Res Commun. 1989 Jun 15;161(2):851-8
pubmed: 2735925
Am J Pathol. 2000 Nov;157(5):1703-11
pubmed: 11073829
Cancer Res. 2010 Jun 15;70(12):4850-8
pubmed: 20501849
J Biol Chem. 1995 Nov 10;270(45):27348-57
pubmed: 7592998
Cancer Res. 1986 Apr;46(4 Pt 1):1795-9
pubmed: 3948164
Oncogene. 2001 Jun 21;20(28):3751-6
pubmed: 11439338
Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15975-80
pubmed: 17043243
Am J Pathol. 1993 Apr;142(4):1119-30
pubmed: 7682762
Am J Pathol. 2008 Aug;173(2):575-85
pubmed: 18599610
Clin Immunol Immunopathol. 1983 Jan;26(1):10-7
pubmed: 6872335
Cancer Res. 2007 Feb 15;67(4):1757-68
pubmed: 17308118
Cancer Res. 2001 Jul 1;61(13):5090-101
pubmed: 11431346
Int J Pharm. 2018 Jun 15;544(2):372-379
pubmed: 29555441
FASEB J. 2003 Jun;17(9):984-92
pubmed: 12773481
Biochimie. 2013 Jun;95(6):1110-9
pubmed: 23507428
Proc Natl Acad Sci U S A. 1994 Mar 1;91(5):1677-81
pubmed: 8127865
Arterioscler Thromb Vasc Biol. 1999 Jun;19(6):1577-81
pubmed: 10364093
Proc Natl Acad Sci U S A. 2008 Jan 22;105(3):985-90
pubmed: 18199835
Ecancermedicalscience. 2014 Nov 26;8:485
pubmed: 25525463
PLoS One. 2009 Jul 08;4(7):e6167
pubmed: 19584911
J Cell Physiol. 1977 May;91(2):297-303
pubmed: 16937
Proc Natl Acad Sci U S A. 1998 May 26;95(11):6355-60
pubmed: 9600969
Am J Physiol Renal Physiol. 2006 Jan;290(1):F148-58
pubmed: 16131647
Leukemia. 2010 Aug;24(8):1476-86
pubmed: 20520642
J Transl Med. 2011 Dec 28;9:221
pubmed: 22204495
J Lipid Res. 2003 May;44(5):927-34
pubmed: 12611907
Eur J Cell Biol. 1985 Jan;36(1):116-27
pubmed: 4038941
Br J Cancer. 2002 Apr 22;86(8):1257-61
pubmed: 11953882
J Cell Physiol. 2007 Mar;210(3):807-18
pubmed: 17154366
J Immunol. 1987 May 1;138(9):2760-3
pubmed: 2952721
Eur J Cell Biol. 2012 Nov-Dec;91(11-12):847-60
pubmed: 22673002
Biochem Biophys Res Commun. 1990 Jul 31;170(2):867-72
pubmed: 1696478
J Cell Biol. 1992 Nov;119(3):629-41
pubmed: 1383237
FASEB J. 2000 Nov;14(14):2185-97
pubmed: 11053239
Am J Physiol Cell Physiol. 2012 Jan 1;302(1):C9-15
pubmed: 21832241
Pharmacol Rev. 2015;67(2):441-61
pubmed: 25769965
Microvasc Res. 2011 Mar;81(2):160-8
pubmed: 21185840
J Biol Chem. 2011 Apr 22;286(16):13801-4
pubmed: 21372130
Clin Cancer Res. 2004 Apr 1;10(7):2393-400
pubmed: 15073116
Protein Sci. 2005 Apr;14(4):1071-81
pubmed: 15741341
Clin Exp Metastasis. 1998 May;16(4):353-7
pubmed: 9626814
Leuk Res. 2011 Nov;35(11):1506-11
pubmed: 21784521
Science. 1986 Jun 6;232(4755):1250-3
pubmed: 2422759
Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1246-51
pubmed: 9990009
Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10857-62
pubmed: 11553814
Biochim Biophys Acta. 2014 Aug;1846(1):161-79
pubmed: 24836679
Cancer Chemother Pharmacol. 2016 Apr;77(4):847-56
pubmed: 26988221
Am J Pathol. 2009 Dec;175(6):2657-67
pubmed: 19875502
Int J Cancer. 2017 Mar 15;140(6):1331-1345
pubmed: 27888521
Nat Rev Cancer. 2008 Aug;8(8):592-603
pubmed: 18650835
Cancer Cell. 2005 Oct;8(4):269-71
pubmed: 16226701
Nature. 1987 Oct 15-21;329(6140):630-2
pubmed: 2443857
Blood. 2005 Apr 1;105(7):2862-8
pubmed: 15591121
J Biol Chem. 2010 Mar 19;285(12):8733-42
pubmed: 20056600
PLoS One. 2014 Mar 14;9(3):e88830
pubmed: 24633367
J Cancer Clin Trials. 2016 Feb;1(1):
pubmed: 28597003
Science. 1983 Feb 25;219(4587):983-5
pubmed: 6823562
J Exp Med. 2010 Aug 30;207(9):1981-93
pubmed: 20713592
J Clin Invest. 2015 Oct 26;125(12):4365-74
pubmed: 26517693
Microvasc Res. 1999 Sep;58(2):89-98
pubmed: 10458924
J Biol Chem. 2003 Nov 7;278(45):44645-9
pubmed: 12947095
FASEB J. 2001 Sep;15(11):2007-9
pubmed: 11511519
Exp Eye Res. 1979 May;28(5):501-14
pubmed: 312738
Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12718-23
pubmed: 14555767
Cancer Lett. 2014 Jan 1;342(1):139-49
pubmed: 24012640
Mol Cancer Res. 2008 Aug;6(8):1268-75
pubmed: 18708359
Cancer Res. 2001 Nov 1;61(21):7992-8
pubmed: 11691824
Science. 1987 Jan 23;235(4787):442-7
pubmed: 2432664
Cancer Res. 1993 Dec 1;53(23):5822-7
pubmed: 7694795
Biochem Biophys Res Commun. 2018 Jan 29;496(1):70-75
pubmed: 29305864
Cancer Res. 2010 Aug 1;70(15):6216-24
pubmed: 20647324
Mol Immunol. 2013 May;54(1):74-83
pubmed: 23220070
Clin Cancer Res. 2012 Jun 1;18(11):3100-11
pubmed: 22498007
Oncoimmunology. 2016 Mar 10;5(7):e1151591
pubmed: 27622015
Clin Cancer Res. 2000 Jun;6(6):2166-74
pubmed: 10873065
PLoS One. 2011;6(8):e22934
pubmed: 21857970
J Exp Clin Cancer Res. 2015 Aug 22;34:85
pubmed: 26297142
J Tongji Med Univ. 1999;19(4):300-3
pubmed: 12938523
PLoS One. 2012;7(10):e47516
pubmed: 23094058
PLoS One. 2014 Oct 16;9(10):e110871
pubmed: 25329517
Oncotarget. 2016 Dec 27;7(52):86026-86038
pubmed: 27852069
Cancer Lett. 2010 Aug 28;294(2):135-8
pubmed: 20199845
Nature. 1989 Apr 13;338(6216):557-62
pubmed: 2467210
J Transl Med. 2014 Aug 21;12:225
pubmed: 25143012
Circ Res. 2009 Feb 27;104(4):428-41
pubmed: 19246687
Crit Rev Immunol. 2008;28(2):109-26
pubmed: 18540827
Arch Ophthalmol. 1990 Oct;108(10):1474-6
pubmed: 1699514
Blood. 2013 Sep 5;122(10):1822-32
pubmed: 23896411
Clin Exp Metastasis. 2012 Oct;29(7):657-62
pubmed: 22692562
Nat Med. 2014 Jul;20(7):741-7
pubmed: 24929950
Diabetologia. 1993 Apr;36(4):282-91
pubmed: 7682976
Cancer Res. 2012 Apr 15;72(8):1909-14
pubmed: 22508695
Circ Res. 2016 Jun 10;118(12):e36-42
pubmed: 27166251
Am J Pathol. 2000 Mar;156(3):899-909
pubmed: 10702407
Biochem Biophys Res Commun. 2016 Mar 4;471(2):290-5
pubmed: 26850851
Oncotarget. 2016 May 3;7(18):25849-61
pubmed: 27029071
J Biol Chem. 1999 Nov 5;274(45):32048-54
pubmed: 10542237
Cancer Res. 1994 Jan 1;54(1):120-3
pubmed: 8261432
Lab Invest. 1997 Apr;76(4):517-31
pubmed: 9111514
J Transl Med. 2013 Nov 06;11:282
pubmed: 24195657
Proc Natl Acad Sci U S A. 1986 Jun;83(12):4167-71
pubmed: 2424019
Theor Biol Med Model. 2013 Feb 12;10:8
pubmed: 23402214
Oncoimmunology. 2015 Feb 18;4(4):e1005521
pubmed: 26137402
Am J Pathol. 1997 Dec;151(6):1523-30
pubmed: 9403702
Physiol Genomics. 2012 Oct 2;44(19):915-24
pubmed: 22911453
Mol Pharmacol. 1997 Jun;51(6):951-62
pubmed: 9187261
Clin Cancer Res. 1999 Feb;5(2):257-65
pubmed: 10037173
Cancer Cell. 2005 Oct;8(4):299-309
pubmed: 16226705
Nature. 1990 Dec 6;348(6301):555-7
pubmed: 1701033
J Cancer Res Clin Oncol. 2005 Nov;131(11):741-50
pubmed: 16136355
J Exp Med. 2007 Mar 19;204(3):605-18
pubmed: 17339405
Curr Pharm Des. 2012;18(10):1319-30
pubmed: 22360558
Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4160-5
pubmed: 11259645
N Engl J Med. 1971 Nov 18;285(21):1182-6
pubmed: 4938153
Eur J Cancer. 2010 May;46(8):1323-32
pubmed: 20236818
Mol Cancer. 2010 Jun 22;9:159
pubmed: 20569465
Drug Resist Updat. 2010 Feb-Apr;13(1-2):16-28
pubmed: 20061178
Biochem Biophys Res Commun. 1988 Dec 15;157(2):793-800
pubmed: 2462419
Dig Liver Dis. 2016 Dec;48(12):1503-1505
pubmed: 27651344
Br J Cancer. 1982 Jan;45(1):35-43
pubmed: 7059463
Nature. 2008 Apr 10;452(7188):759-63
pubmed: 18401410
Acta Pharmacol Sin. 2004 Jun;25(6):812-6
pubmed: 15169637
Br J Cancer. 2003 Oct 20;89(8):1395-9
pubmed: 14562004
J Natl Cancer Inst. 2002 Jan 16;94(2):116-28
pubmed: 11792750
Blood. 2007 Feb 1;109(3):987-94
pubmed: 17032917
J Clin Invest. 2006 Oct;116(10):2610-21
pubmed: 17016557
Cancer Res. 1988 Mar 15;48(6):1671-5
pubmed: 2830969
J Exp Zool. 1993 Nov 1;267(3):245-52
pubmed: 7693860
Acta Pharmacol Sin. 2004 Jan;25(1):54-60
pubmed: 14704123
J Biol Chem. 2011 May 13;286(19):16846-60
pubmed: 21385874
Lancet. 1981 Mar 21;1(8221):636-8
pubmed: 6110864
Oncotarget. 2015 Sep 22;6(28):26119-28
pubmed: 26172294
Heart Vessels. 2010 May;25(3):237-47
pubmed: 20512452
Cancer Immunol Immunother. 2007 May;56(5):641-8
pubmed: 16960692
Cancer Res. 2006 May 15;66(10):5216-23
pubmed: 16707446
Angiogenesis. 2014 Oct;17(4):867-79
pubmed: 24854678
Nature. 1997 Nov 27;390(6658):335-6
pubmed: 9389468
Science. 1992 Dec 11;258(5089):1798-801
pubmed: 1281554
Eur J Immunol. 2004 Feb;34(2):336-44
pubmed: 14768038
Oncol Lett. 2017 Jun;13(6):4390-4396
pubmed: 28599441
Curr Vasc Pharmacol. 2005 Oct;3(4):309-14
pubmed: 16248773
Int J Clin Pharmacol Ther. 1998 Jun;36(6):345-9
pubmed: 9660044
Tumour Biol. 2015 May;36(5):3159-69
pubmed: 25828146
Clin Cancer Res. 1999 Nov;5(11):3711-21
pubmed: 10589791
Angiogenesis. 2014 Jul;17(3):587-601
pubmed: 24254321
Cancer Res. 1997 Mar 1;57(5):963-9
pubmed: 9041202
Int Immunopharmacol. 2019 May;70:156-166
pubmed: 30802678
Eur J Biochem. 2004 May;271(10):1814-9
pubmed: 15128291
Trends Cardiovasc Med. 2007 May;17(4):140-3
pubmed: 17482097
Nat Med. 2005 Sep;11(9):992-7
pubmed: 16127434
F1000Res. 2015 Jan 12;4:9
pubmed: 26097685
Cancer Lett. 2011 Dec 27;313(2):123-8
pubmed: 21974805
Biochemistry. 1985 Sep 24;24(20):5486-94
pubmed: 2866794
Nat Rev Cancer. 2004 Jun;4(6):423-36
pubmed: 15170445
Am J Transl Res. 2018 Jun 15;10(6):1663-1676
pubmed: 30018708
Tumour Biol. 2014 Nov;35(11):10765-71
pubmed: 25073512
Bioessays. 2007 Nov;29(11):1159-68
pubmed: 17935210
J Vet Intern Med. 2011 Jul-Aug;25(4):920-6
pubmed: 21736624
J Biol Chem. 2008 May 23;283(21):14542-51
pubmed: 18364357
Cancer Immunol Immunother. 2019 Mar;68(3):503-515
pubmed: 30652208
J Natl Cancer Inst. 1947 Jun;7(6):425-9
pubmed: 20257043
Clin Immunol Immunopathol. 1986 Mar;38(3):350-6
pubmed: 2935344
J Transl Med. 2013 Oct 24;11:268
pubmed: 24156349
Biochim Biophys Acta. 2015 Oct;1848(10 Pt B):2715-26
pubmed: 25449995
Angiogenesis. 2016 Jan;19(1):95-106
pubmed: 26625874
Food Chem Toxicol. 2010 Nov;48(11):3227-34
pubmed: 20804812
J Biol Chem. 2010 Dec 10;285(50):38923-32
pubmed: 20923780
Biochem J. 2001 Mar 1;354(Pt 2):233-42
pubmed: 11171099
Angiogenesis. 1997;1(1):23-35
pubmed: 14517390
Biochem J. 1988 Feb 15;250(1):1-8
pubmed: 2965576
Eur J Pharmacol. 2014 Jan 15;723:360-7
pubmed: 24239714
Biochem Biophys Res Commun. 1992 Dec 15;189(2):824-31
pubmed: 1281999
Cancer Cell. 2006 Apr;9(4):287-300
pubmed: 16616334
Front Cell Dev Biol. 2016 Mar 31;4:27
pubmed: 27066484
Immunology. 2018 May;154(1):62-68
pubmed: 29460448
Int J Oncol. 2004 May;24(5):1297-304
pubmed: 15067354
Br J Pharmacol. 2009 Apr;156(8):1296-304
pubmed: 19302589
Acta Pathol Microbiol Immunol Scand C. 1985 Aug;93(4):153-9
pubmed: 4050442
Cancer Immunol Immunother. 2012 Mar;61(3):353-62
pubmed: 21915801
Cell Physiol Biochem. 2018;46(6):2561-2575
pubmed: 29758548
Exp Cell Res. 1999 Nov 1;252(2):262-72
pubmed: 10527617