Berry-Enriched Diet in Salt-Sensitive Hypertensive Rats: Metabolic Fate of (Poly)Phenols and the Role of Gut Microbiota.
cardiovascular
dysbiosis
gut metabolism
high salt intake
polyphenols
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
03 Nov 2019
03 Nov 2019
Historique:
received:
14
10
2019
revised:
25
10
2019
accepted:
28
10
2019
entrez:
6
11
2019
pubmed:
7
11
2019
medline:
28
4
2020
Statut:
epublish
Résumé
Diets rich in (poly)phenols are associated with a reduced reduction in the incidence of cardiovascular disorders. While the absorption and metabolism of (poly)phenols has been described, it is not clear how their metabolic fate is affected under pathological conditions. This study evaluated the metabolic fate of berry (poly)phenols in an in vivo model of hypertension as well as the associated microbiota response. Dahl salt-sensitive rats were fed either a low-salt diet (0.26% NaCl) or a high-salt diet (8% NaCl), with or without a berry mixture (blueberries, blackberries, raspberries, Portuguese crowberry and strawberry tree fruit) for 9 weeks. The salt-enriched diet promoted an increase in the urinary excretion of berry (poly)phenol metabolites, while the abundance of these metabolites decreased in faeces, as revealed by UPLC-MS/MS. Moreover, salt and berries modulated gut microbiota composition as demonstrated by 16S rRNA analysis. Some changes in the microbiota composition were associated with the high-salt diet and revealed an expansion of the families
Identifiants
pubmed: 31684148
pii: nu11112634
doi: 10.3390/nu11112634
pmc: PMC6893819
pii:
doi:
Substances chimiques
Glycosides
0
Phenols
0
Phytochemicals
0
Sodium, Dietary
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Agence Nationale de la Recherche
ID : ANR-13-ISV1-0001-01
Organisme : Agence Nationale de la Recherche
ID : ANR-11-IDEX-0003-01
Organisme : Fundação para a Ciência e Tecnologia
ID : FCTANR/BEX-BCM/0001/2013
Organisme : Fundação para a Ciência e Tecnologia
ID : SFRH/BD/103155/2014
Organisme : Fundação para a Ciência e Tecnologia
ID : IF/01097/2013
Organisme : Austrian Science Fund
ID : FWF P26127-B20
Organisme : European Research Council
ID : FunKeyGut 741623
Pays : International
Organisme : Scottish Government
ID : Rural & Environment Science & Analytical Services
Organisme : iNOVA4Health Research Unit
ID : LISBOA-01-0145-FEDER-007344
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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