Galactomannan Is a Biomarker of Fosmanogepix (APX001) Efficacy in Treating Experimental Invasive Pulmonary Aspergillosis.
Animals
Antifungal Agents
/ therapeutic use
Aspergillosis
/ drug therapy
Aspergillus fumigatus
/ drug effects
Biomarkers
/ metabolism
Galactose
/ analogs & derivatives
Immunocompromised Host
Invasive Pulmonary Aspergillosis
/ drug therapy
Lung
/ microbiology
Male
Mannans
/ metabolism
Mice
Microbial Sensitivity Tests
Triazoles
/ therapeutic use
1-aminobenzotriazole
APX001
APX001A
Aspergillus
Aspergillus fumigatus
Gwt1
antifungal
antifungal agents
fosmanogepix
galactomannan
infection model
manogepix
murine
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
20 12 2019
20 12 2019
Historique:
received:
28
09
2019
accepted:
25
10
2019
pubmed:
7
11
2019
medline:
1
9
2020
entrez:
6
11
2019
Statut:
epublish
Résumé
Galactomannan (GM) detection in biological samples has been shown to predict therapeutic response by azoles and polyenes. In a murine invasive pulmonary aspergillosis model, fosmanogepix or posaconazole treatment resulted in an ∼6- to 7-log reduction in conidial equivalents (CE)/g lung tissue after 96 h versus placebo. Changes in GM levels in BAL fluid and serum mirrored reductions in lung CE, with significant decreases seen after 96 h or 72 h for fosmanogepix or posaconazole, respectively (
Identifiants
pubmed: 31685475
pii: AAC.01966-19
doi: 10.1128/AAC.01966-19
pmc: PMC7187618
pii:
doi:
Substances chimiques
Antifungal Agents
0
Biomarkers
0
Mannans
0
Triazoles
0
galactomannan
11078-30-1
posaconazole
6TK1G07BHZ
Galactose
X2RN3Q8DNE
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 Gebremariam et al.
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