Ketone body receptor GPR43 regulates lipid metabolism under ketogenic conditions.
FFAR2
fasting
gut microbiota
ketone body
low carbohydrate
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
19 11 2019
19 11 2019
Historique:
pubmed:
7
11
2019
medline:
3
4
2020
entrez:
6
11
2019
Statut:
ppublish
Résumé
Ketone bodies, including β-hydroxybutyrate and acetoacetate, are important alternative energy sources during energy shortage. β-Hydroxybutyrate also acts as a signaling molecule via specific G protein-coupled receptors (GPCRs); however, the specific associated GPCRs and physiological functions of acetoacetate remain unknown. Here we identified acetoacetate as an endogenous agonist for short-chain fatty acid (SCFA) receptor GPR43 by ligand screening in a heterologous expression system. Under ketogenic conditions, such as starvation and low-carbohydrate diets, plasma acetoacetate levels increased markedly, whereas plasma and cecal SCFA levels decreased dramatically, along with an altered gut microbiota composition. In addition,
Identifiants
pubmed: 31685604
pii: 1912573116
doi: 10.1073/pnas.1912573116
pmc: PMC6876247
doi:
Substances chimiques
Ffar2 protein, mouse
0
Ketone Bodies
0
Ligands
0
Receptors, G-Protein-Coupled
0
Lipoprotein Lipase
EC 3.1.1.34
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
23813-23821Informations de copyright
Copyright © 2019 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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