The generation and propagation of the human alpha rhythm.
alpha
intracranial EEG
laminar
oscillations
thalamocortical
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
19 11 2019
19 11 2019
Historique:
pubmed:
7
11
2019
medline:
3
4
2020
entrez:
6
11
2019
Statut:
ppublish
Résumé
The alpha rhythm is the longest-studied brain oscillation and has been theorized to play a key role in cognition. Still, its physiology is poorly understood. In this study, we used microelectrodes and macroelectrodes in surgical epilepsy patients to measure the intracortical and thalamic generators of the alpha rhythm during quiet wakefulness. We first found that alpha in both visual and somatosensory cortex propagates from higher-order to lower-order areas. In posterior cortex, alpha propagates from higher-order anterosuperior areas toward the occipital pole, whereas alpha in somatosensory cortex propagates from associative regions toward primary cortex. Several analyses suggest that this cortical alpha leads pulvinar alpha, complicating prevailing theories of a thalamic pacemaker. Finally, alpha is dominated by currents and firing in supragranular cortical layers. Together, these results suggest that the alpha rhythm likely reflects short-range supragranular feedback, which propagates from higher- to lower-order cortex and cortex to thalamus. These physiological insights suggest how alpha could mediate feedback throughout the thalamocortical system.
Identifiants
pubmed: 31685634
pii: 1913092116
doi: 10.1073/pnas.1913092116
pmc: PMC6876194
doi:
Banques de données
figshare
['10.6084/m9.figshare.9927125.v2']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
23772-23782Subventions
Organisme : NINDS NIH HHS
ID : K24 NS088568
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB009282
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH099645
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS062092
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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