Concomitant deletion of HRAS and NRAS leads to pulmonary immaturity, respiratory failure and neonatal death in mice.

Animals Bronchi / growth & development Cell Differentiation Mice Mice, Knockout Monomeric GTP-Binding Proteins / deficiency Proto-Oncogene Proteins p21(ras) / deficiency Pulmonary Alveoli / growth & development Respiratory Insufficiency / genetics

Journal

Cell death & disease
ISSN: 2041-4889
Titre abrégé: Cell Death Dis
Pays: England
ID NLM: 101524092

Informations de publication

Date de publication:
04 11 2019
Historique:
received: 15 07 2019
accepted: 21 10 2019
revised: 07 10 2019
entrez: 6 11 2019
pubmed: 7 11 2019
medline: 21 8 2020
Statut: epublish

Résumé

We reported previously that adult (HRAS

Identifiants

DOI: 10.1038/s41419-019-2075-2 PMID: 31685810 PMC: PMC6828777
pubmed: 31685810
doi: 10.1038/s41419-019-2075-2
pii: 10.1038/s41419-019-2075-2
pmc: PMC6828777
doi:

Substances chimiques

Hras protein, mouse EC 3.6.5.2
Monomeric GTP-Binding Proteins EC 3.6.5.2
Nras protein, mouse EC 3.6.5.2
Proto-Oncogene Proteins p21(ras) EC 3.6.5.2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

838

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Auteurs

Rocío Fuentes-Mateos (R)

Centro de Investigación del Cáncer-Instituto de Biología Molecular y Celular del Cáncer (CSIC- Universidad de Salamanca) and CIBERONC, 37007, Salamanca, Spain.
ORCID: 0000-0002-6933-6958

David Jimeno (D)

Centro de Investigación del Cáncer-Instituto de Biología Molecular y Celular del Cáncer (CSIC- Universidad de Salamanca) and CIBERONC, 37007, Salamanca, Spain.

Carmela Gómez (C)

Centro de Investigación del Cáncer-Instituto de Biología Molecular y Celular del Cáncer (CSIC- Universidad de Salamanca) and CIBERONC, 37007, Salamanca, Spain.

Nuria Calzada (N)

Centro de Investigación del Cáncer-Instituto de Biología Molecular y Celular del Cáncer (CSIC- Universidad de Salamanca) and CIBERONC, 37007, Salamanca, Spain.

Alberto Fernández-Medarde (A)

Centro de Investigación del Cáncer-Instituto de Biología Molecular y Celular del Cáncer (CSIC- Universidad de Salamanca) and CIBERONC, 37007, Salamanca, Spain. afm@usal.es.

Eugenio Santos (E)

Centro de Investigación del Cáncer-Instituto de Biología Molecular y Celular del Cáncer (CSIC- Universidad de Salamanca) and CIBERONC, 37007, Salamanca, Spain. esantos@usal.es.
ORCID: 0000-0003-3565-0321

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Concomitant deletion of HRAS and NRAS leads to...
questionsmedicales.fr › Appareil respiratoire › Poumon › Bronches › Concomitant deletion of HRAS and NRAS leads to...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Concomitant deletion of HRAS and NRAS leads to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Concomitant deletion of HRAS and NRAS leads to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Concomitant deletion of HRAS and NRAS leads to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Protéines G monomériques › Concomitant deletion of HRAS and NRAS leads to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes p21(ras) › Concomitant deletion of HRAS and NRAS leads to...
questionsmedicales.fr › Appareil respiratoire › Poumon › Alvéoles pulmonaires › Concomitant deletion of HRAS and NRAS leads to...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Troubles respiratoires › Insuffisance respiratoire › Concomitant deletion of HRAS and NRAS leads to...