Inflammation promotes progression of thrombi in intracranial thrombotic aneurysms.
Aged
Antigens, CD34
Blood Cell Count
Disease Progression
Encephalitis
/ complications
Female
Humans
Immunohistochemistry
Intracranial Aneurysm
/ complications
Intracranial Thrombosis
/ complications
Lectins, C-Type
Leukocyte Count
Lymphocyte Count
Macrophages
/ pathology
Male
Mannose Receptor
Mannose-Binding Lectins
Middle Aged
Neovascularization, Pathologic
/ pathology
Neutrophils
/ pathology
Receptors, Cell Surface
Cerebral aneurysm
Inflammation
Thrombotic aneurysm
Journal
Neurosurgical review
ISSN: 1437-2320
Titre abrégé: Neurosurg Rev
Pays: Germany
ID NLM: 7908181
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
28
06
2019
accepted:
12
09
2019
revised:
20
08
2019
pubmed:
7
11
2019
medline:
1
5
2021
entrez:
6
11
2019
Statut:
ppublish
Résumé
Advances in the understanding of the pathogenesis of arteriosclerosis, abdominal aorta aneurysms and dissections, and carotid artery plaques have focused on chronic inflammation. In this study, we report that inflammatory changes of thrombi contribute to the enlargement and growth of giant intracranial thrombotic aneurysms. Surgical and postmortem samples were collected from 12 cases of large or giant intracranial thrombotic aneurysms diagnosed via pathological investigations. Degeneration of the aneurysmal wall and the infiltration of inflammatory cells in the thrombi were assessed. The number of blood cells and immunohistochemical stain-positive cells was enumerated, and the inflammation and neovascularization in the thrombi were assessed. In all cases, the appearance of inflammatory cells (CD68
Identifiants
pubmed: 31686254
doi: 10.1007/s10143-019-01184-3
pii: 10.1007/s10143-019-01184-3
doi:
Substances chimiques
Antigens, CD34
0
Lectins, C-Type
0
Mannose Receptor
0
Mannose-Binding Lectins
0
Receptors, Cell Surface
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1565-1573Références
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