Update on Autoimmune Diseases Pathogenesis.
Autoimmune diseases
infectious agents
inflammation
micro-RNAs
myeloperoxidase
pathogenesis.
Journal
Current pharmaceutical design
ISSN: 1873-4286
Titre abrégé: Curr Pharm Des
Pays: United Arab Emirates
ID NLM: 9602487
Informations de publication
Date de publication:
2019
2019
Historique:
received:
15
06
2019
accepted:
30
06
2019
entrez:
6
11
2019
pubmed:
7
11
2019
medline:
1
5
2020
Statut:
ppublish
Résumé
Autoimmune diseases result from the interplay of cellular effectors like T and B cells, regulatory cells in addition to molecular factors like cytokines and regulatory molecules. Different electronic databases were searched in a non-systematic way to find out the literature of interest. Pathogenesis of autoimmune diseases involves typical factors such as genetic background including HLA and non HLA system genes, environmental factors such as infectious agents and inflammatory cells mainly T and B lymphocytes abnormally activated leading to immune dysfunction. Other recently reported less typical factors such as micro-RNAs, circular RNAs, myeloperoxidase, vimentine and microbiome dysbiosis seem to be potential target therapies. We aimed in this manuscript to review common factors in the pathogenesis of autoimmune diseases.
Sections du résumé
BACKGROUND
Autoimmune diseases result from the interplay of cellular effectors like T and B cells, regulatory cells in addition to molecular factors like cytokines and regulatory molecules.
METHODS
Different electronic databases were searched in a non-systematic way to find out the literature of interest.
RESULTS
Pathogenesis of autoimmune diseases involves typical factors such as genetic background including HLA and non HLA system genes, environmental factors such as infectious agents and inflammatory cells mainly T and B lymphocytes abnormally activated leading to immune dysfunction. Other recently reported less typical factors such as micro-RNAs, circular RNAs, myeloperoxidase, vimentine and microbiome dysbiosis seem to be potential target therapies.
CONCLUSION
We aimed in this manuscript to review common factors in the pathogenesis of autoimmune diseases.
Identifiants
pubmed: 31686634
pii: CPD-EPUB-99508
doi: 10.2174/1381612825666190709205421
doi:
Substances chimiques
Cytokines
0
MicroRNAs
0
RNA, Circular
0
Vimentin
0
Peroxidase
EC 1.11.1.7
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2947-2952Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.