Evaluation of the Expression Level and Hormone Receptor Association of miR-126 in Breast Cancer.
Breast cancer
Estrogen receptor
HER-2
Progesterone receptor
miR-126
Journal
Indian journal of clinical biochemistry : IJCB
ISSN: 0970-1915
Titre abrégé: Indian J Clin Biochem
Pays: India
ID NLM: 8708303
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
26
02
2018
accepted:
09
06
2018
entrez:
6
11
2019
pubmed:
7
11
2019
medline:
7
11
2019
Statut:
ppublish
Résumé
Breast cancer is a major cause of cancer-related death in women worldwide. miRNAs are new players of breast tumorigenesis, used as diagnostic and prognostic biomarkers. Among various miRNAs, miR-126 has been proposed to have a tumor suppressive role in HER2 positive cancer. However, to have a better understanding of its role, further validation is required. The aim of this study was evaluating miR-126 expression level in breast cancer tissues and investigating its potential association with HER2, estrogen and progesterone receptors. miR-126 expression level was measured in 108 specimens including 78 malignant and 30 normal samples using RT-qPCR. The outcome was statistically analyzed. In silico studies were performed to find the potential mechanism of action, through which miR-126 imposes its function. Down-regulation of miR-126 was observed in tumor samples, as compared to the matched normal tissues. Down-regulation of miR-126 was also associated significantly with the absence of estrogen receptor in malignant samples. No association between miR-126 expression and HER2 status was observed. Our in silico analyses showed the possible role of Crk, PI
Identifiants
pubmed: 31686732
doi: 10.1007/s12291-018-0766-6
pii: 766
pmc: PMC6801275
doi:
Types de publication
Journal Article
Langues
eng
Pagination
451-457Informations de copyright
© Association of Clinical Biochemists of India 2018.
Déclaration de conflit d'intérêts
Conflict of interestAll authors declare that they have no conflict of interest.
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