Comparison of Serum Thyroglobulin Levels in Differentiated Thyroid Cancer Patients Using In-House Developed Radioimmunoassay and Immunoradiometric Procedures.
Differentiated thyroid cancer
Immunoradiometric assay
Radioimmunoassay
Thyroglobulin
Thyroglobulin autoantibodies
Journal
Indian journal of clinical biochemistry : IJCB
ISSN: 0970-1915
Titre abrégé: Indian J Clin Biochem
Pays: India
ID NLM: 8708303
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
22
03
2018
accepted:
09
06
2018
entrez:
6
11
2019
pubmed:
7
11
2019
medline:
7
11
2019
Statut:
ppublish
Résumé
Thyroglobulin (Tg) is a proven tumor marker in the follow-up and post-operative management of patients with differentiated thyroid cancer (DTC). All assays for serum thyroglobulin (s-Tg) are based on immunoassays, however, the assay technique has a bearing on the variations seen in the estimations. We studied this using four in-house developed radioimmunoassays (RIA) and immunoradiometric assays (IRMA). Limit of detection, working range, recovery, dilution test, precision profiles and method comparison were evaluated. All four methods were used for the estimation of s-Tg in DTC patients and also compared for their performance using commercially available Tg IRMA kits from DiaSorin and Izotop. The s-Tg values measured by six different immunoassays showed very significant inter-method correlation (0.84-0.99,
Identifiants
pubmed: 31686734
doi: 10.1007/s12291-018-0768-4
pii: 768
pmc: PMC6801259
doi:
Types de publication
Journal Article
Langues
eng
Pagination
465-471Informations de copyright
© Association of Clinical Biochemists of India 2018.
Déclaration de conflit d'intérêts
Conflict of interestChandrakala Gholve, J. Kumarasamy, Archana Damle, Savita Kulkarni, Meera Venkatesh, Sharmila Banerjee and M. G. R. Rajan declare that they have no conflict of interest.
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