Strontium enhances proliferation and osteogenic behavior of bone marrow stromal cells of mesenchymal and ectomesenchymal origins in vitro.
bone marrow stromal cells
embryonic origin
osteogenic
strontium
Journal
Clinical and experimental dental research
ISSN: 2057-4347
Titre abrégé: Clin Exp Dent Res
Pays: United States
ID NLM: 101692332
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
13
05
2019
revised:
02
06
2019
accepted:
04
06
2019
entrez:
6
11
2019
pubmed:
7
11
2019
medline:
7
11
2019
Statut:
epublish
Résumé
To investigate the effect of increasing Strontium (Sr) concentrations on the growth and osteogenic behavior of human bone marrow stromal cells (BMSCs) from mesenchymal (i.e., fibula) and ectomesenchymal (i.e., mandible) embryonic origins. Fibula and mandible BMSCs were cultured in media without (Ctrl) or with Sr in four diverse concentrations: Sr1, 11.3 × 10 Fibula and mandible BMSCs cultured with Sr4 showed increased proliferation rate, and osteocalcin and osteopontin gene expression together with more evident formation of mineralized nodules, compared all other Sr concentrations. For both cell populations, Sr4 led to lower ALP activity, and ALP gene expression, compared with the other Sr concentrations. BMSCs from mesenchymal (i.e., fibula) and ectomesenchymal (i.e., mandible) embryonic origins showed increased cellular proliferation and osteogenic behavior when cultured with Sr4, in vitro.
Identifiants
pubmed: 31687189
doi: 10.1002/cre2.221
pii: CRE2221
pmc: PMC6820574
doi:
Substances chimiques
Osteocalcin
104982-03-8
Osteopontin
106441-73-0
Alkaline Phosphatase
EC 3.1.3.1
Strontium
YZS2RPE8LE
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
541-550Informations de copyright
©2019 The Authors. Clinical and Experimental Dental Research published by John Wiley & Sons Ltd.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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