Is There Any Relationship between Upper and Lower Limb Impairments in People with Multiple Sclerosis? A Kinematic Quantitative Analysis.
Journal
Multiple sclerosis international
ISSN: 2090-2654
Titre abrégé: Mult Scler Int
Pays: Egypt
ID NLM: 101566861
Informations de publication
Date de publication:
2019
2019
Historique:
received:
03
05
2019
revised:
09
07
2019
accepted:
22
07
2019
entrez:
6
11
2019
pubmed:
7
11
2019
medline:
7
11
2019
Statut:
epublish
Résumé
In people with multiple sclerosis (pwMS), disability is generally assessed on the basis of ambulation abilities, whereas upper limb motor dysfunctions are less frequently considered. Nevertheless, they can severely affect the quality of life of pwMS. To date, it remains mostly unknown whether a relationship exists between upper and lower limb impairments. To investigate the existence of a relationship between upper and lower limb impairments in pwMS based on two fundamental motor tasks, namely walking and hand-to-mouth (HTM) movement. Twenty-eight pwMS with Expanded Disability Status Scale (EDSS) scores in the range of 1-6, and 21 healthy controls (HC) underwent a kinematic analysis of gait and HTM movement performed with a motion capture system. The spatiotemporal parameters for the two tasks were calculated and correlated using Spearman's rank correlation coefficients. The pwMS performed worse than HC on both tasks. Small to large correlations were found between the total HTM movement duration and most of the gait parameters (rho, 0.35-0.68; Both upper and lower limb motor abilities in pwMS worsen as disability increases. Nevertheless, their relationship is only moderate. This finding emphasizes the need for specific tests to quantify disability considering the overall motor function in pwMS.
Sections du résumé
BACKGROUND
BACKGROUND
In people with multiple sclerosis (pwMS), disability is generally assessed on the basis of ambulation abilities, whereas upper limb motor dysfunctions are less frequently considered. Nevertheless, they can severely affect the quality of life of pwMS. To date, it remains mostly unknown whether a relationship exists between upper and lower limb impairments.
AIM
OBJECTIVE
To investigate the existence of a relationship between upper and lower limb impairments in pwMS based on two fundamental motor tasks, namely walking and hand-to-mouth (HTM) movement.
METHODS
METHODS
Twenty-eight pwMS with Expanded Disability Status Scale (EDSS) scores in the range of 1-6, and 21 healthy controls (HC) underwent a kinematic analysis of gait and HTM movement performed with a motion capture system. The spatiotemporal parameters for the two tasks were calculated and correlated using Spearman's rank correlation coefficients.
RESULTS
RESULTS
The pwMS performed worse than HC on both tasks. Small to large correlations were found between the total HTM movement duration and most of the gait parameters (rho, 0.35-0.68;
CONCLUSIONS
CONCLUSIONS
Both upper and lower limb motor abilities in pwMS worsen as disability increases. Nevertheless, their relationship is only moderate. This finding emphasizes the need for specific tests to quantify disability considering the overall motor function in pwMS.
Identifiants
pubmed: 31687212
doi: 10.1155/2019/9149201
pmc: PMC6803720
doi:
Types de publication
Journal Article
Langues
eng
Pagination
9149201Informations de copyright
Copyright © 2019 Giancarlo Coghe et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
Références
J Neurol Sci. 1999 Feb 1;163(1):61-9
pubmed: 10223413
J Int Neuropsychol Soc. 2011 Jul;17(4):643-53
pubmed: 21486517
Gait Posture. 2005 Aug;22(1):1-9
pubmed: 15996586
Hum Mov Sci. 2017 Aug;54:248-252
pubmed: 28575710
Ann Neurol. 2005 Dec;58(6):840-6
pubmed: 16283615
Mult Scler. 2012 May;18(5):639-46
pubmed: 21982871
Mult Scler Relat Disord. 2017 Apr;13:87-92
pubmed: 28427709
Mult Scler. 2015 Oct;21(12):1566-74
pubmed: 25662346
Neurorehabil Neural Repair. 2003 Mar;17(1):66-70
pubmed: 12645447
Neurology. 1983 Nov;33(11):1444-52
pubmed: 6685237
J Rehabil Assist Technol Eng. 2016 Aug 26;3:2055668316663977
pubmed: 31186906
Mult Scler. 2014 Jun;20(7):775-84
pubmed: 24664300
Sci Rep. 2018 Feb 1;8(1):2110
pubmed: 29391520
Gait Posture. 2009 Jan;29(1):138-42
pubmed: 18951800
Gait Posture. 2002 Apr;15(2):113-9
pubmed: 11869904
Mult Scler Int. 2013;2013:875648
pubmed: 23606966
Postgrad Med. 2014 Sep;126(5):102-8
pubmed: 25295653
Gait Posture. 2017 Jan;51:169-173
pubmed: 27776271
Gait Posture. 2017 Jan;51:25-35
pubmed: 27693958
Arch Phys Med Rehabil. 2017 Jul;98(7):1308-1315
pubmed: 28336344
Exp Brain Res. 2012 Dec;223(4):517-24
pubmed: 23111429
Neurorehabil Neural Repair. 2008 Jan-Feb;22(1):31-9
pubmed: 17595381
IEEE Trans Rehabil Eng. 1997 Sep;5(3):253-62
pubmed: 9292291
Cogn Behav Neurol. 2014 Sep;27(3):139-47
pubmed: 25237744
Clin Biomech (Bristol, Avon). 2018 Jan;51:45-50
pubmed: 29179033
Mult Scler. 2016 Dec;22(14):1768-1776
pubmed: 27364324
Curr Neurol Neurosci Rep. 2011 Oct;11(5):507-15
pubmed: 21779953
J Head Trauma Rehabil. 2012 May-Jun;27(3):177-87
pubmed: 21522025
Eur J Neurol. 2009 Feb;16(2):232-9
pubmed: 19146643