Apheresis Therapy for Steroid-Resistant Idiopathic Nephrotic Syndrome: Report on a Case Series.
Journal
Case reports in nephrology
ISSN: 2090-6641
Titre abrégé: Case Rep Nephrol
Pays: United States
ID NLM: 101598418
Informations de publication
Date de publication:
2019
2019
Historique:
received:
11
06
2019
revised:
01
08
2019
accepted:
12
08
2019
entrez:
6
11
2019
pubmed:
7
11
2019
medline:
7
11
2019
Statut:
epublish
Résumé
Idiopathic nephrotic syndrome (INS) represents 15%-30% of adulthood glomerulopathies. Corticosteroids have been the main treatment for decades and are effective in 70% of minimal-change disease patients and ~30% of focal segmental glomerulosclerosis patients. Multidrug-resistant (steroids, calcineurin-inhibitors, cyclophosphamide, mycophenolate-mofetil, rituximab) idiopathic nephrotic syndrome is a major therapeutic challenge in nephrology. Apheresis (double-filtration plasmapheresis or semi specific immunoadsorption) could act by eliminating the circulating factor (apolipoproteinA1b, solubleCD40L, suPAR) increasing glomerular permeability seen in INS. The aim of the study was to report the outcome of three patients with multidrug-resistant INS treated successfully with apheresis.
Identifiants
pubmed: 31687235
doi: 10.1155/2019/7304786
pmc: PMC6803719
doi:
Types de publication
Case Reports
Langues
eng
Pagination
7304786Informations de copyright
Copyright © 2019 Hamza Naciri Bennani et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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