The Impact of Type II Diabetes on Tongue Dysplasia and p16-Related Aging Process: An Experimental Study.
Journal
Analytical cellular pathology (Amsterdam)
ISSN: 2210-7185
Titre abrégé: Anal Cell Pathol (Amst)
Pays: United States
ID NLM: 101541993
Informations de publication
Date de publication:
2019
2019
Historique:
received:
11
06
2019
revised:
25
08
2019
accepted:
09
09
2019
entrez:
6
11
2019
pubmed:
7
11
2019
medline:
4
4
2020
Statut:
epublish
Résumé
To evaluate the effect of streptozotocin-induced experimental diabetes mellitus on p16, p53, Ki67, and Bcl2 expressions and histopathological changes in the tongue of the rats. Twenty-two adult female Sprague-Dawley rats were used. The rats were randomly divided into 2 groups ( Significant differences were observed between the DM group and the control group in terms of epithelial thickness, length of filiform papillae, and width of filiform papillae ( In our study, streptozotocin-induced experimental diabetes mellitus induced p16 expression but did not show any difference in p53, Bcl-2, and Ki67 levels. It should be considered in the studies that the pathological changes at the early stages of the relationship between DM and oral cancer may be related to p16 expression; however, it may also be linked with p16-related aging process.
Identifiants
pubmed: 31687322
doi: 10.1155/2019/3563215
pmc: PMC6800967
doi:
Substances chimiques
Cyclin-Dependent Kinase Inhibitor p16
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3563215Informations de copyright
Copyright © 2019 Eren Altun et al.
Déclaration de conflit d'intérêts
The authors declare that there are no potential conflicts of interest with respect to the research, authorship, or publication of this manuscript.
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