Bisphosphonate Use and Fractures in Adults with Hypophosphatasia.
ALPL
ATYPICAL FEMORAL FRACTURES
GENE MUTATIONS
HYPOPHOSPHATASIA
OSTEOMALACIA
OSTEOPOROSIS
Journal
JBMR plus
ISSN: 2473-4039
Titre abrégé: JBMR Plus
Pays: England
ID NLM: 101707013
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
18
04
2019
revised:
24
06
2019
accepted:
15
07
2019
entrez:
6
11
2019
pubmed:
7
11
2019
medline:
7
11
2019
Statut:
epublish
Résumé
Adults with hypophosphatasia (HPP) may suffer femoral fractures resembling the atypical femoral fractures that can occur with long-term bisphosphonate treatment, and there is an emerging consensus that bisphosphonates should not be used in adults with HPP and low bone mass. However, the spectrum of HPP in adults is wide: ranging from the severely affected-who commonly have osteomalacia-through to the minimally affected. The former typically have biallelic and the latter, heterozygous
Identifiants
pubmed: 31687651
doi: 10.1002/jbm4.10223
pii: JBM410223
pmc: PMC6820463
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e10223Informations de copyright
© 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.
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