Clinical identification of older adults with hypovitaminosis D: Feasibility, acceptability and accuracy of the 'Vitamin D Status Diagnosticator' in primary care.


Journal

The Journal of steroid biochemistry and molecular biology
ISSN: 1879-1220
Titre abrégé: J Steroid Biochem Mol Biol
Pays: England
ID NLM: 9015483

Informations de publication

Date de publication:
03 2020
Historique:
received: 18 07 2019
revised: 11 10 2019
accepted: 29 10 2019
pubmed: 7 11 2019
medline: 7 7 2020
entrez: 6 11 2019
Statut: ppublish

Résumé

The 16-item Vitamin D Status Diagnosticator (VDSD) tool was built to diagnose, without resorting to a blood test, hypovitaminosis D among healthy seniors living at home. The objective of this study was to determine the feasibility of the VDSD by general practitioners (GPs), the acceptability to outpatients, and the diagnostic accuracy of the VDSD in primary care. Ten French GPs were asked from March to May 2015 to perform the VDSD in 30 consecutive outpatients aged ≥70years, living at home, presenting with a history of recurrent falls and/or osteomalacia, and taking no vitamin D supplements. Feasibility was defined as a proportion >70% of VDSD forms fully completed. Completing time, acceptance rate and, when applicable, the reasons for non-completing were assessed, together with the metrological properties of the VDSD to identify hypovitaminosis D ≤75nmol/L, or ≤50nmol/L or ≤25nmol/L. Of the 242 enrolled patients, 218 (mean, 79 ± 6years; 46.3% women) received a VDSD, i.e. completing rate of 90.1%, with an average completing time of 1 min and 48s. The acceptance rate by the patients was 98.8%, and all GPs were satisfied with the tool. The VDSD identified hypovitaminosis D≤75nmol/L with an accuracy of 84.7%, hypovitaminosis D≤50nmol/L with accuracy 75.4%, and hypovitaminosis D≤25nmol/L with accuracy 71.0% (n = 183 assays). The 16-item VDSD can be considered as feasible, acceptable and accurate for diagnosing hypovitaminosis D among older outpatients in primary care without resorting to an expensive blood test.

Identifiants

pubmed: 31689505
pii: S0960-0760(19)30431-5
doi: 10.1016/j.jsbmb.2019.105523
pii:
doi:

Substances chimiques

Vitamins 0
Vitamin D 1406-16-2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

105523

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors report no conflict of interest with this manuscript. They have no relevant financial interest in this manuscript.

Auteurs

Jean-Michel Le Moigno (JM)

Health Faculty, School of Medicine, Angers, France.

Gaëlle Annweiler (G)

Health Faculty, School of Medicine, Angers, France; Department of Geriatric Medicine, Angers University Hospital, Angers University Memory Clinic, Research Center on Autonomy and Longevity, UPRES EA 4638, University of Angers, Angers, France.

Spyridon N Karras (SN)

Division of Endocrinology and Metabolism, First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, Thessaloniki, Greece.

David J Llewellyn (DJ)

University of Exeter Medical School, Exeter, UK.

Jérémie Riou (J)

INSERM, MINT, 1066, University of Angers, Angers, France; Delegation to Clinical Research and Innovation, Angers University Hospital, Angers, France.

Cédric Annweiler (C)

Health Faculty, School of Medicine, Angers, France; Department of Geriatric Medicine, Angers University Hospital, Angers University Memory Clinic, Research Center on Autonomy and Longevity, UPRES EA 4638, University of Angers, Angers, France; Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada. Electronic address: Cedric.Annweiler@chu-angers.fr.

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