Rodent gene drives for conservation: opportunities and data needs.


Journal

Proceedings. Biological sciences
ISSN: 1471-2954
Titre abrégé: Proc Biol Sci
Pays: England
ID NLM: 101245157

Informations de publication

Date de publication:
06 11 2019
Historique:
entrez: 7 11 2019
pubmed: 7 11 2019
medline: 10 6 2020
Statut: ppublish

Résumé

Invasive rodents impact biodiversity, human health and food security worldwide. The biodiversity impacts are particularly significant on islands, which are the primary sites of vertebrate extinctions and where we are reaching the limits of current control technologies. Gene drives may represent an effective approach to this challenge, but knowledge gaps remain in a number of areas. This paper is focused on what is currently known about natural and developing synthetic gene drive systems in mice, some key areas where key knowledge gaps exist, findings in a variety of disciplines relevant to those gaps and a brief consideration of how engagement at the regulatory, stakeholder and community levels can accompany and contribute to this effort. Our primary species focus is the house mouse,

Identifiants

pubmed: 31690240
doi: 10.1098/rspb.2019.1606
pmc: PMC6842857
doi:

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

20191606

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Auteurs

John Godwin (J)

Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA.
Genetic Engineering and Society Center, North Carolina State University, Raleigh, NC 27695, USA.
W. M. Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695, USA.

Megan Serr (M)

Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA.

S Kathleen Barnhill-Dilling (SK)

Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC 27695, USA.

Dimitri V Blondel (DV)

Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA.

Peter R Brown (PR)

Health and Biosecurity, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Canberra, Australian Capital Territory, Australia.

Karl Campbell (K)

Island Conservation, Charles Darwin Avenue, Puerto Ayora, Galapagos Islands, Ecuador.
School of Agriculture and Food Sciences, The University of Queensland, Gatton, Queensland, Australia.

Jason Delborne (J)

Genetic Engineering and Society Center, North Carolina State University, Raleigh, NC 27695, USA.
Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC 27695, USA.

Alun L Lloyd (AL)

Department of Mathematics, North Carolina State University, Raleigh, NC 27695, USA.

Kevin P Oh (KP)

National Wildlife Research Center, US Department of Agriculture, Fort Collins, CO 80521, USA.

Thomas A A Prowse (TAA)

School of Mathematical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.

Royden Saah (R)

Genetic Engineering and Society Center, North Carolina State University, Raleigh, NC 27695, USA.
Island Conservation, Charles Darwin Avenue, Puerto Ayora, Galapagos Islands, Ecuador.

Paul Thomas (P)

School of Medicine, The University of Adelaide, Adelaide, South Australia, Australia.
South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.

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Classifications MeSH