Blonanserin suppresses impulsive action in rats.

Animals Antipsychotic Agents / pharmacology Behavior, Animal / drug effects Impulsive Behavior / drug effects Male Mental Disorders / drug therapy Piperazines / pharmacology Piperidines / pharmacology Rats Rats, Wistar Reaction Time
1-PP Antipsychotics Impulsive behavior

Journal

Journal of pharmacological sciences
ISSN: 1347-8648
Titre abrégé: J Pharmacol Sci
Pays: Japan
ID NLM: 101167001

Informations de publication

Date de publication:
Nov 2019
Historique:
received: 05 04 2019
revised: 12 08 2019
accepted: 11 09 2019
pubmed: 7 11 2019
medline: 28 3 2020
entrez: 7 11 2019
Statut: ppublish

Résumé

High impulsivity will increase the risk of criminal behavior, drug abuse, and suicide. We chose two drugs by following a strategy recently we proposed for identifying potential anti-impulsivity drugs, and examined the effects on impulsive action in rats by using a 3-choice serial reaction time task. We showed that the administration of blonanserin, an atypical antipsychotic, reduced impulsive actions in a U-shaped manner. 1-(2-Pyriidinyl)-piperazine, an active metabolite of buspirone or tandospirone, also slightly reduced impulsive actions, though it impaired motor functions. These results affirm the validity of our strategy, but require its refinement for developing anti-impulsivity drugs.

Identifiants

DOI: 10.1016/j.jphs.2019.09.013 PMID: 31690490
pubmed: 31690490
pii: S1347-8613(19)35718-4
doi: 10.1016/j.jphs.2019.09.013
pii:
doi:

Substances chimiques

Antipsychotic Agents 0
Piperazines 0
Piperidines 0
blonanserin AQ316B4F8C

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

127-130

Informations de copyright

Copyright © 2019 The Authors. Production and hosting by Elsevier B.V. All rights reserved.

Auteurs

Naoya Nishitani (N)

Department of Neuropharmacology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15 W7 Kita-ku, Sapporo, 060-8638, Japan.

Hitomi Sasamori (H)

Department of Neuropharmacology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15 W7 Kita-ku, Sapporo, 060-8638, Japan; Research Fellow of the Japan Society for the Promotion of Science, Tokyo, 102-0083, Japan.

Yu Ohmura (Y)

Department of Neuropharmacology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15 W7 Kita-ku, Sapporo, 060-8638, Japan. Electronic address: gwd0701@yahoo.co.jp.

Takayuki Yoshida (T)

Department of Neuropharmacology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15 W7 Kita-ku, Sapporo, 060-8638, Japan.

Mitsuhiro Yoshioka (M)

Department of Neuropharmacology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15 W7 Kita-ku, Sapporo, 060-8638, Japan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Blonanserin suppresses impulsive action in rats.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Psychoanaleptiques › Tranquillisants › Neuroleptiques › Blonanserin suppresses impulsive action in rats.
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement animal › Blonanserin suppresses impulsive action in rats.
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement impulsif › Blonanserin suppresses impulsive action in rats.
questionsmedicales.fr › Troubles mentaux › Blonanserin suppresses impulsive action in rats.
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipérazines › Blonanserin suppresses impulsive action in rats.
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › Blonanserin suppresses impulsive action in rats.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Blonanserin suppresses impulsive action in rats.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Wistar › Blonanserin suppresses impulsive action in rats.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Temps de réaction › Blonanserin suppresses impulsive action in rats.