Prospective associations of cardiovascular disease with physical performance and disability : A longitudinal cohort study in the Osteoarthritis Initiative.
Cardiovascular disease
Chair stand time
Gait Speed
Osteoarthritis
WOMAC
Journal
Wiener klinische Wochenschrift
ISSN: 1613-7671
Titre abrégé: Wien Klin Wochenschr
Pays: Austria
ID NLM: 21620870R
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
14
06
2019
accepted:
04
10
2019
revised:
22
09
2019
pubmed:
7
11
2019
medline:
18
9
2020
entrez:
7
11
2019
Statut:
ppublish
Résumé
Literature regarding cardiovascular disease (CVD) and incident physical performance limitations and disability in older people is equivocal. This study aimed to investigate whether CVD is longitudinally associated with incident physical performance limitations and disability in a large population-based sample. This was an 8‑year prospective study using data collected as part of the Osteoarthritis Initiative. Participants were community-dwelling adults with knee osteoarthritis or at high risk for this condition. Diagnosed CVD was self-reported. Physical performance was assessed with measures of chair stand time and gait speed, whereas disability was assessed with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Longitudinal associations between CVD and changes in physical performance tests (chair stand time and gait speed) and disability score were analyzed using generalized linear models with repeated measurements. The analyzed sample comprised 4796 adults (mean age 61.2 years, 58.5% female), of whom 313 people (6.5%) reported CVD at baseline. During 8 years of follow-up, after adjustment for 11 potential confounders measured at baseline, those with CVD experienced a worse profile in chair stand time over the 8‑year follow-up period than those without CVD (p = 0.006). In a cohort of middle-aged and older adults with knee osteoarthritis or at high risk for this condition those with CVD experienced a worse profile in chair stand time over the 8‑year follow-up period than those without CVD; however, CVD was not significantly associated with an increased incidence of poor gait speed and disability over 8 years of follow-up. Importantly, no associations were observed when utilizing propensity score matching.
Sections du résumé
BACKGROUND
BACKGROUND
Literature regarding cardiovascular disease (CVD) and incident physical performance limitations and disability in older people is equivocal.
AIMS
OBJECTIVE
This study aimed to investigate whether CVD is longitudinally associated with incident physical performance limitations and disability in a large population-based sample.
METHODS
METHODS
This was an 8‑year prospective study using data collected as part of the Osteoarthritis Initiative. Participants were community-dwelling adults with knee osteoarthritis or at high risk for this condition. Diagnosed CVD was self-reported. Physical performance was assessed with measures of chair stand time and gait speed, whereas disability was assessed with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Longitudinal associations between CVD and changes in physical performance tests (chair stand time and gait speed) and disability score were analyzed using generalized linear models with repeated measurements.
RESULTS
RESULTS
The analyzed sample comprised 4796 adults (mean age 61.2 years, 58.5% female), of whom 313 people (6.5%) reported CVD at baseline. During 8 years of follow-up, after adjustment for 11 potential confounders measured at baseline, those with CVD experienced a worse profile in chair stand time over the 8‑year follow-up period than those without CVD (p = 0.006).
CONCLUSION
CONCLUSIONS
In a cohort of middle-aged and older adults with knee osteoarthritis or at high risk for this condition those with CVD experienced a worse profile in chair stand time over the 8‑year follow-up period than those without CVD; however, CVD was not significantly associated with an increased incidence of poor gait speed and disability over 8 years of follow-up. Importantly, no associations were observed when utilizing propensity score matching.
Identifiants
pubmed: 31691029
doi: 10.1007/s00508-019-01567-y
pii: 10.1007/s00508-019-01567-y
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
73-78Subventions
Organisme : Department of Health
ID : ICA-CL-2017-03-001
Pays : United Kingdom
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