Differences in nicotine intake and effects from electronic and combustible cigarettes among dual users.
Dual users
JUUL PK profile
e-cigarette dependence
e-cigarettes
nicotine pharmacokinetics
subjective effects
Journal
Addiction (Abingdon, England)
ISSN: 1360-0443
Titre abrégé: Addiction
Pays: England
ID NLM: 9304118
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
20
01
2019
revised:
23
05
2019
accepted:
29
10
2019
pubmed:
7
11
2019
medline:
18
2
2021
entrez:
7
11
2019
Statut:
ppublish
Résumé
To describe systemic nicotine exposure and subjective effects of electronic cigarettes (e-cigarettes) in people who use both e-cigarettes and cigarettes (dual users), including within-subject comparisons of e-cigarette and cigarette use. Two-arm, counterbalanced cross-over study. Participants used their usual brand of e-cigarette or cigarette during a standardized session in a 2-week study. Hospital research ward, San Francisco, CA, USA. Thirty-six healthy (eight women, 28 men) participants. Plasma nicotine was analyzed by gas chromatography-tandem mass spectrometry; nicotine withdrawal, urge to smoke and vape, affective states, craving, satisfaction and psychological reward were measured by standardized questionnaires. Compared with cigarettes, average maximum plasma nicotine concentration (C Systemic nicotine exposure was, on average, lower with single use of e-cigarettes compared with cigarettes, and e-cigarettes were judged to be less satisfying and rewarding and reduced craving less than cigarettes.
Identifiants
pubmed: 31691397
doi: 10.1111/add.14884
pmc: PMC7339816
mid: NIHMS1057729
doi:
Substances chimiques
Nicotine
6M3C89ZY6R
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
757-767Subventions
Organisme : NCRR NIH HHS
ID : UL1 RR024131
Pays : United States
Organisme : NIDA NIH HHS
ID : P30 DA012393
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA039264
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA180890
Pays : United States
Organisme : NHLBI NIH HHS
ID : U54 HL147127
Pays : United States
Informations de copyright
© 2020 Society for the Study of Addiction.
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