Sex-based differences in the response to dexamethasone in bacterial meningitis: Analysis of the European dexamethasone in adulthood bacterial meningitis study.
corticosteroids
infectious diseases
inflammation
neurology
Journal
British journal of clinical pharmacology
ISSN: 1365-2125
Titre abrégé: Br J Clin Pharmacol
Pays: England
ID NLM: 7503323
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
13
06
2019
revised:
28
09
2019
accepted:
13
10
2019
pubmed:
7
11
2019
medline:
29
7
2021
entrez:
7
11
2019
Statut:
ppublish
Résumé
Inflammatory markers have been found at higher concentrations in women than men with bacterial meningitis. To investigate sex-based differences in the response to dexamethasone, we performed a post hoc analysis of a double-blind, randomised multicentre trial of dexamethasone (10 mg, 4 times daily for 4 days) vs placebo in adults with bacterial meningitis. The primary outcome measure was the Glasgow outcome scale score at 8 weeks and interaction tests were used to examine subgroup differences. Between June 1993 and December 2001, 301 patients (56% male) were randomly assigned to a treatment group: 157 received dexamethasone and 144 placebo. Although dexamethasone reduced the risk of unfavourable outcome to a greater extent in women (relative risk [RR] 0.42, 95% confidence interval [CI] 0.21-0.86, P = .02) than men (RR 0.79, 95% CI 0.41-1.51, P = .55), on interaction testing (ratio of RR women:men 0.53, 95% CI 0.20-1.39, P = .19) patient sex was not a significant modifier of the effect of dexamethasone.
Identifiants
pubmed: 31692016
doi: 10.1111/bcp.14163
pmc: PMC7015757
doi:
Substances chimiques
Biomarkers
0
Dexamethasone
7S5I7G3JQL
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
386-391Subventions
Organisme : Academisch Medisch Centrum
ID : AMC Fellowship
Pays : International
Organisme : European Academy of Neurology
ID : EAN Research Fellowship Grant
Pays : International
Organisme : European Research Council
ID : ERC Starting Grant
Pays : International
Organisme : European Society of Clinical Microbiology and Infectious Diseases
ID : ESCMID Research Grant
Pays : International
Organisme : ZonMw
ID : NWO-Veni-Grant [916.13.078]
Pays : International
Organisme : ZonMw
ID : NWO-Vidi-Grant [016.116.358]
Pays : International
Organisme : ZonMw
ID : 016.116.358
Pays : International
Organisme : Netherlands Organization for Health Research and Development
ID : 916.13.078
Pays : International
Informations de copyright
© 2019 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.
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