3-O-Sulfation of Heparan Sulfate Enhances Tau Interaction and Cellular Uptake.


Journal

Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543

Informations de publication

Date de publication:
27 01 2020
Historique:
received: 11 10 2019
revised: 29 10 2019
pubmed: 7 11 2019
medline: 5 1 2021
entrez: 7 11 2019
Statut: ppublish

Résumé

Prion-like transcellular spreading of tau in Alzheimer's Disease (AD) is mediated by tau binding to cell surface heparan sulfate (HS). However, the structural determinants for tau-HS interaction are not well understood. Microarray and SPR assays of structurally defined HS oligosaccharides show that a rare 3-O-sulfation (3-O-S) of HS significantly enhances tau binding. In Hs3st1

Identifiants

pubmed: 31692167
doi: 10.1002/anie.201913029
pmc: PMC6982596
mid: NIHMS1058783
doi:

Substances chimiques

tau Proteins 0
Heparitin Sulfate 9050-30-0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1818-1827

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL093339
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG062344
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL144970
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL094463
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG069039
Pays : United States
Organisme : NIA NIH HHS
ID : R37 AG019391
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM103390
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA225784
Pays : United States

Informations de copyright

© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Auteurs

Jing Zhao (J)

Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA.

Yanan Zhu (Y)

Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, USA.

Xuehong Song (X)

Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, USA.

Yuanyuan Xiao (Y)

Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA.

Guowei Su (G)

Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, USA.

Xinyue Liu (X)

Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA.

Zhangjie Wang (Z)

Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, USA.

Yongmei Xu (Y)

Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, USA.

Jian Liu (J)

Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, USA.

David Eliezer (D)

Department of Biochemistry, Program in Structural Biology, Weill Cornell Medical College, New York, NY, USA.

Trudy F Ramlall (TF)

Department of Biochemistry, Program in Structural Biology, Weill Cornell Medical College, New York, NY, USA.

Guy Lippens (G)

Toulouse Biotechnology Institute, CNRS, INRA, INSA, University of Toulouse, 31077, Toulouse, France.

James Gibson (J)

Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA.

Fuming Zhang (F)

Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA.
Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY, USA.

Robert J Linhardt (RJ)

Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA.
Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY, USA.

Lianchun Wang (L)

Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, USA.
Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, USA.

Chunyu Wang (C)

Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA.
Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA.
Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY, USA.

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Classifications MeSH