Tuberculosis and HIV co-infection in Congolese children: risk factors of death.
Antitubercular Agents
/ administration & dosage
Child
Child, Preschool
Coinfection
Cross-Sectional Studies
Democratic Republic of the Congo
/ epidemiology
Directly Observed Therapy
Female
HIV Infections
/ epidemiology
Humans
Male
Nutritional Status
Prevalence
Risk Factors
Tuberculosis
/ drug therapy
Child
Co-infection
HIV
Lubumbashi
Mortality
Tuberculosis
Journal
The Pan African medical journal
ISSN: 1937-8688
Titre abrégé: Pan Afr Med J
Pays: Uganda
ID NLM: 101517926
Informations de publication
Date de publication:
2019
2019
Historique:
received:
22
04
2019
accepted:
18
08
2019
entrez:
7
11
2019
pubmed:
7
11
2019
medline:
26
11
2019
Statut:
epublish
Résumé
Human immunodeficiency virus (HIV) and tuberculosis (TB) are the leading causes of death from infectious disease worldwide. The prevalence of HIV among children with TB in moderate to high prevalence countries ranges between 10% and 60%. This study aimed to determine the prevalence of HIV infection among children treated for TB in Directly Observed Treatment Short-Course (DOTS) clinics in Lubumbashi and to identify risk of death during this co-infection. This is a cross-sectional study of children under-15, treated for tuberculosis from January 1, 2013 to December 31, 2015. Clinical, paraclinical and outcome data were collected in 22 DOTS of Lubumbashi. A statistical comparison was made between dead and survived HIV-infected TB children. We performed the multivariate analyzes and the significance level set at p-value <0.05. A total of 840 children with TB were included. The prevalence of HIV infection was 20.95% (95% CI: 18.34-23.83%). The mortality rate was higher for HIV-infected children (47.73%) compared to HIV-uninfected children (17.02%) (p<0.00001). Age <5 years (aOR=6.50 [1.96-21.50]), a poor nutritional status (aOR=23.55 [8.20-67.64]), and a negative acid-fast bacilli testing (aOR=4.51 [1.08-18.70]) were associated with death during anti-TB treatment. TB and HIV co-infection is a reality in pediatric settings in Lubumbashi. High mortality highlights the importance of early management.
Identifiants
pubmed: 31692828
doi: 10.11604/pamj.2019.33.326.18911
pii: PAMJ-33-326
pmc: PMC6815491
doi:
Substances chimiques
Antitubercular Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
326Informations de copyright
© Olivier Mukuku et al.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
Références
Trans R Soc Trop Med Hyg. 1994 Mar-Apr;88(2):178-81
pubmed: 8036665
PLoS Med. 2016 Oct 25;13(10):e1002152
pubmed: 27780211
AIDS. 2010 Jun 19;24(10):1501-8
pubmed: 20505496
Rev Mal Respir. 2012 Nov;29(9):1095-103
pubmed: 23200581
BMC Infect Dis. 2008 Jul 18;8:94
pubmed: 18637205
Acta Med Croatica. 2011 Mar;65(1):3-10
pubmed: 21568068
Int J Tuberc Lung Dis. 2008 Feb;12(2):186-92
pubmed: 18230252
Int J Tuberc Lung Dis. 2012 Apr;16(4):462-7
pubmed: 22640512
Clin Infect Dis. 2009 Jan 1;48(1):108-14
pubmed: 19049436
Int J Tuberc Lung Dis. 2002 Aug;6(8):672-8
pubmed: 12150478
PLoS Pathog. 2012 Feb;8(2):e1002464
pubmed: 22363214
Int J Tuberc Lung Dis. 2004 May;8(5):636-47
pubmed: 15137548
Am J Respir Crit Care Med. 2006 May 15;173(10):1078-90
pubmed: 16484674
Pan Afr Med J. 2017 Sep 27;28:82
pubmed: 29255552
Int J Tuberc Lung Dis. 2005 Dec;9(12):1299-304
pubmed: 16466050
BMC Pediatr. 2014 Mar 03;14:61
pubmed: 24581267
Clin Infect Dis. 2010 May 15;50 Suppl 3:S184-94
pubmed: 20397947
BMC Infect Dis. 2014;14 Suppl 1:S5
pubmed: 24564453
Arch Pediatr. 2005 Aug;12(8):1215-20
pubmed: 15935628
BMC Pediatr. 2008 Jan 11;8:1
pubmed: 18186944
Pediatrics. 2012 Dec;130(6):e1433-40
pubmed: 23184116
J Infect Dis. 2007 Aug 15;196 Suppl 1:S76-85
pubmed: 17624829
Int J Tuberc Lung Dis. 2010 Aug;14(8):973-9
pubmed: 20626941
PLoS One. 2010 Oct 12;5(10):e13338
pubmed: 20967279
Int J Tuberc Lung Dis. 2000 May;4(5):448-54
pubmed: 10815739
Trop Med Int Health. 2010 May;15(5):496-501
pubmed: 20230572
AIDS. 1997 Jul 15;11(9):1151-8
pubmed: 9233463
Scand J Infect Dis. 2009;41(6-7):450-5
pubmed: 20001277
PLoS One. 2013;8(2):e56248
pubmed: 23457534
Int J Tuberc Lung Dis. 2010 Jan;14(1):79-85
pubmed: 20003699
Lancet Infect Dis. 2008 Aug;8(8):498-510
pubmed: 18652996
PLoS Med. 2014 May 27;11(5):e1001650
pubmed: 24866364
Bull Soc Pathol Exot. 2008 Oct;101(4):303-7
pubmed: 18956810
J Acquir Immune Defic Syndr. 2009 Dec;52(5):623-8
pubmed: 19730270