Association between serum homocysteine level and cognitive function in middle-aged type 2 diabetes mellitus patients.
Adult
Case-Control Studies
Cognitive Dysfunction
/ blood
Cross-Sectional Studies
Diabetes Mellitus, Type 2
/ blood
Female
Homocysteine
/ blood
Humans
Indonesia
/ epidemiology
Male
Middle Aged
Neuropsychological Tests
/ statistics & numerical data
Risk Factors
Surveys and Questionnaires
/ statistics & numerical data
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
05
04
2019
accepted:
17
10
2019
entrez:
7
11
2019
pubmed:
7
11
2019
medline:
19
3
2020
Statut:
epublish
Résumé
Type-2 diabetes mellitus (T2DM) is strongly associated with various complications, including cognitive impairment. Diabetic complication is related with structural and functional changes of brain. Studies investigated that homocysteine as an independent risk factor of several organ complications. This marker might have a role in pathogenesis of cognitive impairment in T2DM patients. We aimed to know the association between serum homocysteine level and cognitive impairment in middle-aged T2DM populations. The study was a cross-sectional study involving 97 T2DM patients aged <60 years old. Cognitive assessment was based on validated Indonesian version of Montreal Cognitive Assessment (MoCA-INA) test. Besides, serum homocysteine level (Hcy) was measured based on standard laboratory assay. Filling out the questionnaire of MoCA-INA was conducted when patients came to take the blood sample. This study used independent t-test, chi-square and multivariate logistic regression model to analyze the data. There were 47 subjects (48.5%) with mild cognitive impairment (MCI). Delayed recall was the most impaired domain (94.8%). There was no significant mean difference of serum Hcy level in MCI and non-MCI group (11.99±3.27 μmol/L vs 12.36±4.07 μmol/L respectively, p = 0.62). Final model of logistic regression showed no association between serum Hcy and cognitive function after adjusting confounding variables (OR: 1.778; 95%CI: 0.69-4.54). Further investigation involving slight elderly T2DM patients with larger sample size should be conducted to confirm this finding.
Identifiants
pubmed: 31693691
doi: 10.1371/journal.pone.0224611
pii: PONE-D-19-09158
pmc: PMC6834332
doi:
Substances chimiques
Homocysteine
0LVT1QZ0BA
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0224611Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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